DNA-Spermidine | CAS# 37217-88-2 | against radiation-induced leukopenia

MedKoo Cat#: 581129 | Name: DNA-Spermidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DNA-Spermidine used DNA-Spermidine; DNA Spermidine; DA-51; DA 51; DA51. Ability of DNA and spermidine to affect the activity of restriction endonucleases from several bacterial species. Models for the interaction of spermine and DNA were studied by performing conformational energy calculations on spermine and molecular mechanics calculations on major and minor groove complexes of spermine and oligomers of DNA. Docked into the major groove of B-DNA, spermine stabilizes the complex by maximizing interactions between proton acceptors on the oligomer and proton donors on spermine. This is achieved by bending the major groove of DNA over spermine and altering oligomer sugar puckering and interstrand phosphate distances. By comparison, Liquori's minor groove model appears to be less stable than the major groove model. This evidence favors a preferential binding of spermine to certain sites in DNA, which provides a powerful force for the modification of DNA conformation.

Chemical Structure

DNA-Spermidine

CAS#37217-88-2

Theoretical Analysis

MedKoo Cat#: 581129

Name: DNA-Spermidine

CAS#: 37217-88-2

Chemical Formula:

Exact Mass:

Molecular Weight:

Elemental Analysis:

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DNA-Spermidine; DNA Spermidine; DA-51; DA 51; DA51

IUPAC/Chemical Name

DNA-Spermidine

InChi Key

InChi Code

SMILES Code

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Carrasco IS, Bastos FM, Munford ML, Ramos EB, Rocha MS. Atomic Force Microscopy of spermidine-induced DNA condensates on silicon surfaces. Mater Sci Eng C Mater Biol Appl. 2012 Jan 1;32(1):36-9. doi: 10.1016/j.msec.2011.09.008. Epub 2011 Sep 21. PubMed PMID: 23177769. 2: Liu YH, Zhang J, Chen YB, Li YP, Hu L. [A fluoride-sensor for kink structure in DNA condensation process]. Guang Pu Xue Yu Guang Pu Fen Xi. 2014 Jan;34(1):157-61. Chinese. PubMed PMID: 24783552. 3: Lin Z, Wang C, Feng X, Liu M, Li J, Bai C. The observation of the local ordering characteristics of spermidine-condensed DNA: atomic force microscopy and polarizing microscopy studies. Nucleic Acids Res. 1998 Jul 1;26(13):3228-34. PubMed PMID: 9628923; PubMed Central PMCID: PMC147677. 4: Skuridin SG, Kadykov VA, Shashkov VS, Evdokimov IuM, Varshavskiĭ IaM. [Formation of the compact form of DNA in solution after reaction with spermidine]. Mol Biol (Mosk). 1978 Mar-Apr;12(2):413-20. Russian. PubMed PMID: 349364. 5: Hultgren A, Rau DC. Exclusion of alcohols from spermidine-DNA assemblies: probing the physical basis of preferential hydration. Biochemistry. 2004 Jun 29;43(25):8272-80. PubMed PMID: 15209524. 6: Raspaud E, Durand D, Livolant F. Interhelical spacing in liquid crystalline spermine and spermidine-DNA precipitates. Biophys J. 2005 Jan;88(1):392-403. Epub 2004 Oct 15. PubMed PMID: 15489310; PubMed Central PMCID: PMC1305016. 7: Baeza I, Ibáñez M, Wong C, Chávez P, Gariglio P, Oró J. Possible prebiotic significance of polyamines in the condensation, protection, encapsulation, and biological properties of DNA. Orig Life Evol Biosph. 1991-1992;21(4):225-42. PubMed PMID: 1668678. 8: Baeza I, Gariglio P, Rangel LM, Chavez P, Cervantes L, Arguello C, Wong C, Montañez C. Electron microscopy and biochemical properties of polyamine-compacted DNA. Biochemistry. 1987 Oct 6;26(20):6387-92. PubMed PMID: 3322379. 9: Boldt JL, Kepple KV, Cassell GD, Segall AM. Spermidine biases the resolution of Holliday junctions by phage lambda integrase. Nucleic Acids Res. 2007;35(3):716-27. Epub 2006 Dec 19. PubMed PMID: 17182631; PubMed Central PMCID: PMC1807965. 10: Murphy JC, Fox GE, Willson RC. Enhancement of anion-exchange chromatography of DNA using compaction agents. J Chromatogr A. 2003 Jan 17;984(2):215-21. PubMed PMID: 12564692. 11: Tsuya A, Kaneta K, Okawa T, Nakama M, Watari T. [Protective effect of DNA-spermidine (DA-51) against radiation-induced leukopenia -a study on breast cancer patients receiving postoperative prophylactic irradiation (author's transl)]. Nihon Igaku Hoshasen Gakkai Zasshi. 1976 Aug 25;36(8):702-9. Japanese. PubMed PMID: 792805. 12: Tsuya A, Kaneta K, Okawa T, Watari T, Asakura H. [Protective effect of DNA-spermidine (DA-51) against radiation-induced leukopenia. (Preliminary report)--a study on breast cancer patients receiving prophylactic irradiation (author's transl)]. Nihon Igaku Hoshasen Gakkai Zasshi. 1974 Jan 25;34(1):26-32. Japanese. PubMed PMID: 4605894. 13: Romain N, Dandrifosse G, Forget P, Lepoint A. Effect of prostaglandin E2 on the small intestine of indomethacin-treated rats. Life Sci. 1987 Sep 7;41(10):1199-205. PubMed PMID: 3114578. 14: Fell PL, Hudson AJ, Reynolds MA, Usman N, Akhtar S. Cellular uptake properties of a 2'-amino/2'-O-methyl-modified chimeric hammerhead ribozyme targeted to the epidermal growth factor receptor mRNA. Antisense Nucleic Acid Drug Dev. 1997 Aug;7(4):319-26. PubMed PMID: 9303183.