MS37452 is a modulator of methyl-lysine. It acts by inducing transcriptional derepression of p16/CDKN2A by disrupting CBX7ChD binding to H3K27me3 at the INK4A/ARF locus in PC3 prostate cancer cells. MS37452 derepresses transcription of Polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells.
MedKoo Cat#: 562266
Name: MS37452
CAS#: 423748-02-1
Chemical Formula: C22H26N2O5
Exact Mass: 398.1842
Molecular Weight: 398.45
Elemental Analysis: C, 66.32; H, 6.58; N, 7.03; O, 20.08
The following data is based on the product molecular weight 398.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
