SSJ-183 | CAS#1187533-34-1 | antimalarial agent

MedKoo Cat#: 562257 | Name: SSJ-183

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SSJ-183 is an antimalarial agent.

Chemical Structure

SSJ-183

CAS#1187533-34-1

Theoretical Analysis

MedKoo Cat#: 562257

Name: SSJ-183

CAS#: 1187533-34-1

Chemical Formula: C25H22N4O

Exact Mass: 394.1794

Molecular Weight: 394.47

Elemental Analysis: C, 76.12; H, 5.62; N, 14.20; O, 4.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SSJ-183; SSJ 183; SSJ183;

IUPAC/Chemical Name

N,N-diethyl-5-pyridin-4-yliminobenzo[a]phenoxazin-9-amine

InChi Key

HBSWMATYASLRBW-QYQHSDTDSA-N

InChi Code

InChI=1S/C25H22N4O/c1-3-29(4-2)18-9-10-21-23(15-18)30-24-16-22(27-17-11-13-26-14-12-17)19-7-5-6-8-20(19)25(24)28-21/h5-16H,3-4H2,1-2H3/b27-22-

SMILES Code

CCN(CC)C1=CC(OC2=C/C(C3=CC=CC=C3C2=N4)=N/C5=CC=NC=C5)=C4C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 394.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mizukawa Y, Ge JF, Bakar Md A, Itoh I, Scheurer C, Wittlin S, Brun R, Matsuoka H, Ihara M. Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites. Bioorg Med Chem. 2014 Jul 15;22(14):3749-52. doi: 10.1016/j.bmc.2014.04.066. Epub 2014 May 10. PubMed PMID: 24856305. 2: Schleiferböck S, Scheurer C, Ihara M, Itoh I, Bathurst I, Burrows JN, Fantauzzi P, Lotharius J, Charman SA, Morizzi J, Shackleford DM, White KL, Brun R, Wittlin S. In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models. Drug Des Devel Ther. 2013 Nov 15;7:1377-84. doi: 10.2147/DDDT.S51298. eCollection 2013. PubMed PMID: 24255594; PubMed Central PMCID: PMC3832383. 3: Lu J, Arai C, Md AB, Ihara M. Plasmodium berghei proteome changes in response to SSJ-183 treatment. Bioorg Med Chem. 2011 Jul 1;19(13):4144-7. doi: 10.1016/j.bmc.2011.04.051. Epub 2011 May 11. PubMed PMID: 21622001. 4: Ge JF, Arai C, Yang M, Bakar Md A, Lu J, Ismail NS, Wittlin S, Kaiser M, Brun R, Charman SA, Nguyen T, Morizzi J, Itoh I, Ihara M. Discovery of Novel Benzo[a]phenoxazine SSJ-183 as a Drug Candidate for Malaria. ACS Med Chem Lett. 2010 Jul 12;1(7):360-4. doi: 10.1021/ml100120a. eCollection 2010 Oct 14. PubMed PMID: 24900219; PubMed Central PMCID: PMC4007839.