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MedKoo Cat#: 562234 | Name: Methyllucidone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methyllucidone is a STAT3 inhibitor. It acts by regulating the expression of the protein tyrosine phosphatase MEG2.

Chemical Structure

Methyllucidone
Methyllucidone
CAS#19956-54-8

Theoretical Analysis

MedKoo Cat#: 562234

Name: Methyllucidone

CAS#: 19956-54-8

Chemical Formula: C16H14O4

Exact Mass: 270.0892

Molecular Weight: 270.28

Elemental Analysis: C, 71.10; H, 5.22; O, 23.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Methyllucidone;
IUPAC/Chemical Name
(2Z)-4-Methoxy-2-[(E)-1-methoxy-3-phenylprop-2-enylidene]cyclopent-4-ene-1,3-dione
InChi Key
FITVJPYUOAZKPN-PBMBQWDMSA-N
InChi Code
InChI=1S/C16H14O4/c1-19-13(9-8-11-6-4-3-5-7-11)15-12(17)10-14(20-2)16(15)18/h3-10H,1-2H3/b9-8+,15-13-
SMILES Code
O=C1/C(C(C(OC)=C1)=O)=C(OC)\C=C\C2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 270.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jin Y, Kim YH, Park JY, Lee YJ, Oh HM, Choi SK, Han DC, Kwon BM. Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells. Bioorg Med Chem Lett. 2018 Mar 1;28(5):853-857. doi: 10.1016/j.bmcl.2018.02.012. Epub 2018 Feb 8. PubMed PMID: 29456111. 2: Cui Y, Wu J, Jung SC, Kim GO, Kyeong Ko R, Lee HJ, Yoo ES, Kang HK, Suk K, Eun SY. Neuroprotective effect of methyl lucidone against microglia-mediated neurotoxicity. Eur J Pharmacol. 2012 Sep 5;690(1-3):4-12. doi: 10.1016/j.ejphar.2012.05.041. Epub 2012 Jun 7. PubMed PMID: 22683871. 3: Oh HM, Choi SK, Lee JM, Lee SK, Kim HY, Han DC, Kim HM, Son KH, Kwon BM. Cyclopentenediones, inhibitors of farnesyl protein transferase and anti-tumor compounds, isolated from the fruit of Lindera erythrocarpa Makino. Bioorg Med Chem. 2005 Nov 15;13(22):6182-7. Epub 2005 Aug 1. PubMed PMID: 16055336.