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MedKoo Cat#: 562230 | Name: BUR1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BUR1 is a selective BMP upregulator. It acts by increasing expression of Inhibitor of DNA binding 1 (Id1) and inducing BMP2 and PTGS2 expression.

Chemical Structure

BUR1
BUR1
CAS#23000-46-6

Theoretical Analysis

MedKoo Cat#: 562230

Name: BUR1

CAS#: 23000-46-6

Chemical Formula: C16H17N5

Exact Mass: 279.1484

Molecular Weight: 279.34

Elemental Analysis: C, 68.79; H, 6.13; N, 25.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BUR1; BUR-1; BUR 1; BMP upregulator 1; BMP upregulator-1;
IUPAC/Chemical Name
1-Phenyl-4-(piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
InChi Key
AMRPAMSVFKIGHT-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H17N5/c1-3-7-13(8-4-1)21-16-14(11-19-21)15(17-12-18-16)20-9-5-2-6-10-20/h1,3-4,7-8,11-12H,2,5-6,9-10H2
SMILES Code
C12=NC=NC(N3CCCCC3)=C1C=NN2C4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 279.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation. Mol Cell Biol. 2013 Jan;33(1):170-82. doi: 10.1128/MCB.01233-12. Epub 2012 Oct 29. PubMed PMID: 23109428; PubMed Central PMCID: PMC3536304. 11: García A, Collin A, Calvo O. Sub1 associates with Spt5 and influences RNA polymerase II transcription elongation rate. Mol Biol Cell. 2012 Nov;23(21):4297-312. doi: 10.1091/mbc.E12-04-0331. Epub 2012 Sep 12. PubMed PMID: 22973055; PubMed Central PMCID: PMC3484106. 12: Qiu H, Hu C, Gaur NA, Hinnebusch AG. Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex. EMBO J. 2012 Aug 15;31(16):3494-505. doi: 10.1038/emboj.2012.188. Epub 2012 Jul 13. PubMed PMID: 22796944; PubMed Central PMCID: PMC3419927. 13: Shchebet A, Karpiuk O, Kremmer E, Eick D, Johnsen SA. Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function. Cell Cycle. 2012 Jun 1;11(11):2122-7. doi: 10.4161/cc.20548. Epub 2012 Jun 1. PubMed PMID: 22592529. 14: Ding D, Muthuswamy S, Meier I. Functional interaction between the Arabidopsis orthologs of spindle assembly checkpoint proteins MAD1 and MAD2 and the nucleoporin NUA. Plant Mol Biol. 2012 Jun;79(3):203-16. doi: 10.1007/s11103-012-9903-4. Epub 2012 Mar 29. PubMed PMID: 22457071. 15: McKay SL, Johnson TL. An investigation of a role for U2 snRNP spliceosomal components in regulating transcription. PLoS One. 2011 Jan 24;6(1):e16077. doi: 10.1371/journal.pone.0016077. PubMed PMID: 21283673; PubMed Central PMCID: PMC3025917. 16: Clausing E, Mayer A, Chanarat S, Müller B, Germann SM, Cramer P, Lisby M, Strässer K. The transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress. J Biol Chem. 2010 Dec 31;285(53):41665-74. doi: 10.1074/jbc.M110.193292. Epub 2010 Nov 12. PubMed PMID: 21075850; PubMed Central PMCID: PMC3009894. 17: Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL. CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev. 2010 Oct 15;24(20):2303-16. doi: 10.1101/gad.1968210. PubMed PMID: 20952539; PubMed Central PMCID: PMC2956209. 18: García A, Rosonina E, Manley JL, Calvo O. Sub1 globally regulates RNA polymerase II C-terminal domain phosphorylation. Mol Cell Biol. 2010 Nov;30(21):5180-93. doi: 10.1128/MCB.00819-10. Epub 2010 Sep 7. PubMed PMID: 20823273; PubMed Central PMCID: PMC2953048. 19: Mayer A, Lidschreiber M, Siebert M, Leike K, Söding J, Cramer P. Uniform transitions of the general RNA polymerase II transcription complex. Nat Struct Mol Biol. 2010 Oct;17(10):1272-8. doi: 10.1038/nsmb.1903. Epub 2010 Sep 5. 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