MedKoo Cat#: 584359 | Name: Disulergine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Disulergine is a dopamine receptor agonist and prolactin release-inhibiting 8 alpha-amino-ergoline.

Chemical Structure

Disulergine
Disulergine
CAS#59032-40-5

Theoretical Analysis

MedKoo Cat#: 584359

Name: Disulergine

CAS#: 59032-40-5

Chemical Formula: C17H24N4O2S

Exact Mass: 348.1620

Molecular Weight: 348.47

Elemental Analysis: C, 58.60; H, 6.94; N, 16.08; O, 9.18; S, 9.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Disulergine; CH 29717; CH 29-717; CM 29717
IUPAC/Chemical Name
N,N-Dimethyl-N'-((8 alpha)-6-methylergolin-8-yl)sulfamide
InChi Key
VUEGYUOUAAVYAS-JGGQBBKZSA-N
InChi Code
InChI=1S/C17H24N4O2S/c1-20(2)24(22,23)19-12-8-14-13-5-4-6-15-17(13)11(9-18-15)7-16(14)21(3)10-12/h4-6,9,12,14,16,18-19H,7-8,10H2,1-3H3/t12-,14+,16+/m0/s1
SMILES Code
O=S(N[C@@H](C[C@@]12[H])CN(C)[C@]1([H])CC3=CNC4=C3C2=CC=C4)(N(C)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 348.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Spada A, Bassetti M, Reza-Elahi F, Arosio M, Gil-Del-Alamo P, Vallar L. Differential transduction of dopamine signal in different subtypes of human growth hormone-secreting adenomas. J Clin Endocrinol Metab. 1994 Feb;78(2):411-7. PubMed PMID: 7906281. 2: Spada A, Sartorio A, Bassetti M, Pezzo G, Giannattasio G. In vitro effect of dopamine on growth hormone (GH) release from human GH-secreting pituitary adenomas. J Clin Endocrinol Metab. 1982 Oct;55(4):734-40. PubMed PMID: 7107817. 3: Markó M. Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines. Eur J Pharmacol. 1984 Jun 1;101(3-4):263-6. PubMed PMID: 6468500. 4: Flückiger E, Briner U, Bürki HR, Marbach P, Wagner HR, Doepfner W. Two novel prolactin release-inhibiting 8 alpha-amino-ergolines. Experientia. 1979 Dec 15;35(12):1677-8. PubMed PMID: 520501. 5: Spada A, Bassetti M, Martino E, Giannattasio G, Beck-Peccoz P, Sartorio A, Vallar L, Baschieri L, Pinchera A, Faglia G. In vitro studies on TSH secretion and adenylate cyclase activity in a human TSH-secreting pituitary adenoma. Effects of somatostatin and dopamine. J Endocrinol Invest. 1985 Jun;8(3):193-8. PubMed PMID: 2863299. 6: Nielsen EB, Randrup K, Andersen PH. Amphetamine discrimination: effects of dopamine receptor agonists. Eur J Pharmacol. 1989 Jan 31;160(2):253-62. PubMed PMID: 2569406. 7: Grossman A, Yeo T, Delitala G, Hathway NR, Besser GM. Two new dopamine agonists that are long acting in vivo but short acting in vitro. Clin Endocrinol (Oxf). 1980 Dec;13(6):595-9. PubMed PMID: 7226572. 8: Prysor-Jones RA, Jenkins JS. Effect of bromocriptine, ergotamine and other ergot alkaloids on the hormone secretion and growth of a rat pituitary tumour. J Endocrinol. 1980 Jul;86(1):147-53. PubMed PMID: 7430884.