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MedKoo Cat#: 562226 | Name: RCGD-423
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RCGD 423 is a GP10 signaling modulator which binds to domain 2 of GP130 causing atypical GP130 homodimerization, reducing the number of GP130 molecules available to dimerize with IL-6 family cytokine receptors. In a study, RCGD 423 reduced cartilage degradation, structural damage and the generation of osteophytes.

Chemical Structure

RCGD-423
RCGD-423
CAS#108237-91-8

Theoretical Analysis

MedKoo Cat#: 562226

Name: RCGD-423

CAS#: 108237-91-8

Chemical Formula: C15H11BrN2S

Exact Mass: 329.9826

Molecular Weight: 331.23

Elemental Analysis: C, 54.39; H, 3.35; Br, 24.12; N, 8.46; S, 9.68

Price and Availability

Size Price Availability Quantity
10mg USD 150.00 Ready to ship
25mg USD 250.00 Ready to ship
50mg USD 450.00 Ready to ship
100mg USD 750.00 Ready to ship
200mg USD 1,250.00 Ready to ship
500mg USD 2,450.00 Ready to ship
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Related CAS #
No Data
Synonym
RCGD-423; RCGD 423; RCGD423; Regulator of cartilage growth and differentiation (RCGD) 423;
IUPAC/Chemical Name
N-(4-Bromophenyl)-4-phenyl-1,3-thiazol-2-amine
InChi Key
OUFYYVAASPLOAA-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H11BrN2S/c16-12-6-8-13(9-7-12)17-15-18-14(10-19-15)11-4-2-1-3-5-11/h1-10H,(H,17,18)
SMILES Code
BrC1=CC=C(NC2=NC(C3=CC=CC=C3)=CS2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
RCGD423 is a gp130 modulator and targets IL6-beta
In vitro activity:
TBD
In vivo activity:
Taking advantage of a molecule with the robust ability to promote Myc expression through binding of GP130 and activation of Jak/Stat signaling, mice were topically treated for 48 hours to determine the effect of RCGD423 on Stat signaling and Myc expression. Topical treatment of animals in telogen (day 50) with RCGD423 led to a robust acceleration of the hair cycle (Fig 6h), as well as minor hyperproliferation of the interfollicular epidermis.Total protein preps from skin treated with 2 topical doses of RCGD423 (50uM) show increased c-Myc, n-Myc and Ldha protein levels compared to animals that received 2 topical doses of vehicle control. Animals treated with RCGD423 (50uM) show pigmentation and hair growth, indicative of entry into anagen, after 5 doses. RCGD423 binds to GP130, a co-receptor for Jak-Stat signaling, and activates Stat-3. It was found that Stat-3 was activated in HFSCs by RCGD423 after topical treatment by immunostaining with phospho-Stat3 antibody (Fig 6g). This also correlated with induction of Ki67 in HFSCs in the same tissue (Fig 6g). IHC for pStat1 and pStat5 suggested that RCGD423 does not dramatically affect these other Stat family members (Supplementary Figure 5). Reference: Nat Cell Biol. 2017 Sep; 19(9): 1017–1026. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657543/
Solvent mg/mL mM
Solubility
DMSO 34.0 102.60
Ethanol 34.0 102.60
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 331.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol. 2017 Sep;19(9):1017-1026. doi: 10.1038/ncb3575. Epub 2017 Aug 14. PMID: 28812580; PMCID: PMC5657543.
In vitro protocol:
TBD
In vivo protocol:
1. Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol. 2017 Sep;19(9):1017-1026. doi: 10.1038/ncb3575. Epub 2017 Aug 14. PMID: 28812580; PMCID: PMC5657543.
1: Flores A, Schell J, Krall AS, et al. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol. 2017;19(9):1017-1026. doi:10.1038/ncb3575 2: Liu, N. Q. (2018). High-throughput screened small molecule targeting glycoprotein 130 prevents articular cartilage degeneration and promotes repair in osteoarthritis. Digital Medicine, 4(2), 51-53. 3: Collison, J. (2018). Targeting gp130 aids cartilage repair. Nature Reviews Rheumatology, 14(4), 182-182.