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MedKoo Cat#: 562221 | Name: TPO-Agonist-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TPO-Agonist-1 is a potent and selective thrombopoietin (TPO) receptor agonist.

Chemical Structure

TPO-Agonist-1
TPO-Agonist-1
CAS#1033040-23-1

Theoretical Analysis

MedKoo Cat#: 562221

Name: TPO-Agonist-1

CAS#: 1033040-23-1

Chemical Formula: C25H22N8O2

Exact Mass: 466.1866

Molecular Weight: 466.50

Elemental Analysis: C, 64.37; H, 4.75; N, 24.02; O, 6.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
TPO-Agonist-1; TPO Agonist 1; TPOAgonist1;
IUPAC/Chemical Name
1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazole-4,5-dione 4-[2-[2-hydroxy-3'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]hydrazone]
InChi Key
IIBBJCNVTRCTDV-HPNDGRJYSA-N
InChi Code
InChI=1S/C25H22N8O2/c1-14-10-11-19(12-15(14)2)33-25(35)22(16(3)30-33)27-26-21-9-5-8-20(23(21)34)17-6-4-7-18(13-17)24-28-31-32-29-24/h4-13,26,34H,1-3H3,(H,28,29,31,32)/b27-22+
SMILES Code
O=C(N(C1=CC=C(C)C(C)=C1)N=C/2C)C2=N\NC3=C(O)C(C4=CC=CC(C5=NNN=N5)=C4)=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 466.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Perdomo J. Role of romiplostim in splenectomized and nonsplenectomized patients with immune thrombocytopenia. Immunotargets Ther. 2016 Feb 22;5:1-7. doi: 10.2147/ITT.S80648. eCollection 2016. Review. PubMed PMID: 27529057; PubMed Central PMCID: PMC4970631. 2: Kuter DJ. The biology of thrombopoietin and thrombopoietin receptor agonists. Int J Hematol. 2013 Jul;98(1):10-23. doi: 10.1007/s12185-013-1382-0. Epub 2013 Jul 3. Review. PubMed PMID: 23821332. 3: Zeng Y, Duan X, Xu J, Ni X. TPO receptor agonist for chronic idiopathic thrombocytopenic purpura. Cochrane Database Syst Rev. 2011 Jul 6;(7):CD008235. doi: 10.1002/14651858.CD008235.pub2. Review. PubMed PMID: 21735426. 4: Cohn CS, Bussel JB. Romiplostim: a second-generation thrombopoietin agonist. Drugs Today (Barc). 2009 Mar;45(3):175-88. doi: 10.1358/dot.2009.45.3.1343793. Review. PubMed PMID: 19436840. 5: Harker LA. Therapeutic cytokine stimulation of thrombocytopoiesis. Transfus Sci. 1998 Jun;19(2):149-62. Review. PubMed PMID: 10187040.