MedKoo Cat#: 562217 | Name: nNOS-IN-25

Description:

WARNING: This product is for research use only, not for human or veterinary use.

nNOS-IN-25 is a potent, selective, and cell permeable neuronal nitric oxide synthase (nNOS) inhibitor.

Chemical Structure

nNOS-IN-25
nNOS-IN-25
CAS#1895092-16-6

Theoretical Analysis

MedKoo Cat#: 562217

Name: nNOS-IN-25

CAS#: 1895092-16-6

Chemical Formula: C21H22N4

Exact Mass: 330.1844

Molecular Weight: 330.43

Elemental Analysis: C, 76.33; H, 6.71; N, 16.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
nNOS-IN-25; nNOS IN 25; nNOSIN25; nNOS inhibitor 25; nNOS inhibitor-25;
IUPAC/Chemical Name
4-(2-(((2-Amino-4-methylquinolin-7-yl)methyl)amino)ethyl)-2-methylbenzonitrile
InChi Key
GMHLRRHIOCDMQV-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H22N4/c1-14-9-16(3-5-18(14)12-22)7-8-24-13-17-4-6-19-15(2)10-21(23)25-20(19)11-17/h3-6,9-11,24H,7-8,13H2,1-2H3,(H2,23,25)
SMILES Code
N#CC1=CC=C(CCNCC2=CC=C3C(C)=CC(N)=NC3=C2)C=C1C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 330.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wu QQ, Xiao Y, Duan MX, Yuan Y, Jiang XH, Yang Z, Liao HH, Deng W, Tang QZ. Aucubin protects against pressure overload-induced cardiac remodelling via β3-AR-nNOS cascades. Br J Pharmacol. 2018 Feb 15. doi: 10.1111/bph.14164. [Epub ahead of print] PubMed PMID: 29447430. 2: Singh VK, Lal B. Nitric oxide (NO) stimulates steroidogenesis and folliculogenesis in fish. Reproduction. 2017 Feb;153(2):133-146. Epub 2016 Nov 4. PubMed PMID: 27815560. 3: Leger PL, Bonnin P, Moretti R, Tanaka S, Duranteau J, Renolleau S, Baud O, Charriaut-Marlangue C. Early Recruitment of Cerebral Microcirculation by Neuronal Nitric Oxide Synthase Inhibition in a Juvenile Ischemic Rat Model. Cerebrovasc Dis. 2016;41(1-2):40-9. doi: 10.1159/000441663. Epub 2015 Nov 25. PubMed PMID: 26599266. 4: Vitcheva V, Simeonova R, Kondeva-Burdina M, Mitcheva M. Selective Nitric Oxide Synthase Inhibitor 7-Nitroindazole Protects against Cocaine-Induced Oxidative Stress in Rat Brain. Oxid Med Cell Longev. 2015;2015:157876. doi: 10.1155/2015/157876. Epub 2015 Oct 20. PubMed PMID: 26576217; PubMed Central PMCID: PMC4630414. 5: Bongartz LG, Soni S, Cramer MJ, Steendijk P, Gaillard CA, Verhaar MC, Doevendans PA, van Veen TA, Joles JA, Braam B. Neuronal nitric oxide synthase-dependent amelioration of diastolic dysfunction in rats with chronic renocardiac syndrome. Cardiorenal Med. 2015 Feb;5(1):69-78. doi: 10.1159/000370052. Epub 2015 Jan 16. PubMed PMID: 25759702; PubMed Central PMCID: PMC4327336. 6: Dastgheib M, Moezi L. Acute and chronic effects of agomelatine on intravenous penthylenetetrazol-induced seizure in mice and the probable role of nitric oxide. Eur J Pharmacol. 2014 Aug 5;736:10-5. doi: 10.1016/j.ejphar.2014.04.039. Epub 2014 May 4. PubMed PMID: 24803306. 7: Drury PP, Davidson JO, Mathai S, van den Heuij LG, Ji H, Bennet L, Tan S, Silverman RB, Gunn AJ. nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep. Neuropharmacology. 2014 Aug;83:62-70. doi: 10.1016/j.neuropharm.2014.03.017. Epub 2014 Apr 12. PubMed PMID: 24726307; PubMed Central PMCID: PMC4077724. 8: Hiroaki-Sato VA, Sales AJ, Biojone C, Joca SR. Hippocampal nNOS inhibition induces an antidepressant-like effect: involvement of 5HT1A receptors. Behav Pharmacol. 2014 Jun;25(3):187-96. doi: 10.1097/FBP.0000000000000035. PubMed PMID: 24710314. 9: Misra S, Kuhad A, Chopra K. Neurobiological effect of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, in experimental paradigm of Alzheimer's disease. Indian J Exp Biol. 2013 Dec;51(12):1086-93. PubMed PMID: 24579374. 10: El-Mas MM, Abdel-Rahman AA. Endothelial and neuronal nitric oxide synthases variably modulate the oestrogen-mediated control of blood pressure and cardiovascular autonomic control. Clin Exp Pharmacol Physiol. 2014 Mar;41(3):246-54. doi: 10.1111/1440-1681.12207. PubMed PMID: 24471817; PubMed Central PMCID: PMC3967713. 11: Chien SJ, Lin KM, Kuo HC, Huang CF, Lin YJ, Huang LT, Tain YL. Two different approaches to restore renal nitric oxide and prevent hypertension in young spontaneously hypertensive rats: l-citrulline and nitrate. Transl Res. 2014 Jan;163(1):43-52. doi: 10.1016/j.trsl.2013.09.008. Epub 2013 Oct 8. PubMed PMID: 24113064. 12: Padayachee ER, Whiteley CG. Etiology of Alzheimer's disease: kinetic, thermodynamic and fluorimetric analyses of interactions of pseudo Aβ-peptides with neuronal nitric oxide synthase. Neuropeptides. 2013 Oct;47(5):321-7. doi: 10.1016/j.npep.2013.08.001. Epub 2013 Aug 23. PubMed PMID: 24034554. 13: Shabeeh H, Melikian N, Dworakowski R, Casadei B, Chowienczyk P, Shah AM. Differential role of endothelial versus neuronal nitric oxide synthase in the regulation of coronary blood flow during pacing-induced increases in cardiac workload. Am J Physiol Heart Circ Physiol. 2013 May;304(9):H1277-82. doi: 10.1152/ajpheart.00927.2012. Epub 2013 Mar 11. PubMed PMID: 23479261; PubMed Central PMCID: PMC3652090. 14: Bulbul A, Bulbul T, Sevimli A, Yilmaz O. The effect of dietary supplementation of nitric oxide donor and inhibitor on nNOS expression in and motility of the small intestine of broilers. Biotech Histochem. 2013 Jul;88(5):258-66. doi: 10.3109/10520295.2013.769631. Epub 2013 Mar 11. PubMed PMID: 23477594. 15: Padayachee ER, Whiteley CG. Interaction of glycine zipper fragments of Aβ-peptides with neuronal nitric oxide synthase: kinetic, thermodynamic and spectrofluorimetric analysis. Neuropeptides. 2013 Jun;47(3):171-8. doi: 10.1016/j.npep.2012.12.006. Epub 2013 Jan 31. PubMed PMID: 23375441. 16: Tandai-Hiruma M, Kato K, Kemuriyama T, Ohta H, Tashiro A, Hagisawa K, Nishida Y. High blood pressure enhances brain stem neuronal nitric oxide synthase activity in Dahl salt-sensitive rats. Clin Exp Pharmacol Physiol. 2013 Mar;40(3):197-204. doi: 10.1111/1440-1681.12049. PubMed PMID: 23278407. 17: Heydarpour P, Salehi-Sadaghiani M, Javadi-Paydar M, Rahimian R, Fakhfouri G, Khosravi M, Khoshkish S, Gharedaghi MH, Ghasemi M, Dehpour AR. Estradiol reduces depressive-like behavior through inhibiting nitric oxide/cyclic GMP pathway in ovariectomized mice. Horm Behav. 2013 Feb;63(2):361-9. doi: 10.1016/j.yhbeh.2012.12.005. Epub 2012 Dec 19. PubMed PMID: 23262264. 18: Demiralay E, Saglam IY, Ozdamar EN, Sehirli AO, Sener G, Saglam E. nNOS expression in the brain of rats after burn and the effect of the ACE inhibitor captopril. Burns. 2013 Aug;39(5):897-904. doi: 10.1016/j.burns.2012.10.008. Epub 2012 Nov 6. PubMed PMID: 23137627. 19: Budec M, Markovic D, Vignjevic S, Mitrovic O, Dikic D, Koko V, Cokic VP. Neuronal nitric oxide synthase mediates the effect of ethanol on IgA. Alcohol Alcohol. 2013 Jan-Feb;48(1):53-8. doi: 10.1093/alcalc/ags110. Epub 2012 Oct 11. PubMed PMID: 23059423. 20: Suborov EV, Smetkin AA, Kondratiev TV, Valkov AY, Kuzkov VV, Kirov MY, Bjertnaes LJ. Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy. BMC Anesthesiol. 2012 Jun 21;12:10. doi: 10.1186/1471-2253-12-10. PubMed PMID: 22720843; PubMed Central PMCID: PMC3441363.