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MedKoo Cat#: 562213 | Name: ASP-6537

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ASP-6537, also known as FK881, is a selective and reversible cyclooxygenase-1 (COX-1) inhibitor.

Chemical Structure

ASP-6537
ASP-6537
CAS#524699-72-7

Theoretical Analysis

MedKoo Cat#: 562213

Name: ASP-6537

CAS#: 524699-72-7

Chemical Formula: C17H17N3O3

Exact Mass: 311.1270

Molecular Weight: 311.34

Elemental Analysis: C, 65.58; H, 5.50; N, 13.50; O, 15.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
ASP-6537; ASP 6537; ASP6537; FK-881; FK 881; FK881;
IUPAC/Chemical Name
3-Methoxy-1,5-bis(4-methoxyphenyl)-1H-1,2,4-triazole
InChi Key
OBAICMYWONZOSZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H17N3O3/c1-21-14-8-4-12(5-9-14)16-18-17(23-3)19-20(16)13-6-10-15(22-2)11-7-13/h4-11H,1-3H3
SMILES Code
COC1=CC=C(C2=NC(OC)=NN2C3=CC=C(OC)C=C3)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 311.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sakata C, Suzuki KI, Morita Y, Kawasaki T. Additive antithrombotic effect of ASP6537, a selective cyclooxygenase (COX)-1 inhibitor, in combination with clopidogrel in guinea pigs. Eur J Pharmacol. 2017 Mar 5;798:72-76. doi: 10.1016/j.ejphar.2017.01.015. Epub 2017 Jan 14. PubMed PMID: 28095326. 2: Ofosu FA. Effective, selective and specific inhibition of COX-1 may overcome the "aspirin paradox". Thromb Res. 2013 Jul;132(1):1-2. doi: 10.1016/j.thromres.2013.04.011. Epub 2013 May 7. PubMed PMID: 23664562. 3: Sakata C, Kawasaki T, Kato Y, Abe M, Suzuki K, Ohmiya M, Funatsu T, Morita Y, Okada M. ASP6537, a novel highly selective cyclooxygenase-1 inhibitor, exerts potent antithrombotic effect without "aspirin dilemma". Thromb Res. 2013 Jul;132(1):56-62. doi: 10.1016/j.thromres.2013.03.005. Epub 2013 Mar 22. PubMed PMID: 23522855. 4: Imanishi J, Morita Y, Yoshimi E, Kuroda K, Masunaga T, Yamagami K, Kuno M, Hamachi E, Aoki S, Takahashi F, Nakamura K, Miyata S, Ohkubo Y, Mutoh S. Pharmacological profile of FK881(ASP6537), a novel potent and selective cyclooxygenase-1 inhibitor. Biochem Pharmacol. 2011 Oct 1;82(7):746-54. doi: 10.1016/j.bcp.2011.06.035. Epub 2011 Jul 2. PubMed PMID: 21745460.