Trimosulfa | CAS#8064-90-2 | antibiotic combination

MedKoo Cat#: 562211 | Name: Trimosulfa

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trimosulfa is a fixed antibiotic combination. It is widely used for mild-to-moderate bacterial infections and as prophylaxis against opportunistic infections.

Chemical Structure

Trimosulfa

CAS#8064-90-2

Theoretical Analysis

MedKoo Cat#: 562211

Name: Trimosulfa

CAS#: 8064-90-2

Chemical Formula: C24H29N7O6S

Exact Mass: 0.0000

Molecular Weight: 543.59

Elemental Analysis: C, 53.03; H, 5.38; N, 18.04; O, 17.66; S, 5.90

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 600.00

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Trimosulfa; Trimethoprimsulfa; Trimethoprim-sulfamethoxazole; Trimforte; Sulfamethoxazole-trimethoprim; TMP-SMX;

IUPAC/Chemical Name

4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide compound with 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine (1:1)

InChi Key

WZRJTRPJURQBRM-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

SMILES Code

O=S(C1=CC=C(N)C=C1)(NC2=NOC(C)=C2)=O.COC3=C(OC)C(OC)=CC(CC4=C(N)N=C(N)N=C4)=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 543.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zunza M, Gray DM, Young T, Cotton M, Zar HJ. Isoniazid for preventing tuberculosis in HIV-infected children. Cochrane Database Syst Rev. 2017 Aug 29;8:CD006418. doi: 10.1002/14651858.CD006418.pub3. Review. PubMed PMID: 28850172; PubMed Central PMCID: PMC5618450. 2: Ruzagira E, Baisley K, Kamali A, Biraro S, Grosskurth H; Working Group on Linkage to HIV Care. Linkage to HIV care after home-based HIV counselling and testing in sub-Saharan Africa: a systematic review. Trop Med Int Health. 2017 Jul;22(7):807-821. doi: 10.1111/tmi.12888. Epub 2017 May 22. Review. PubMed PMID: 28449385. 3: Cherazard R, Epstein M, Doan TL, Salim T, Bharti S, Smith MA. Antimicrobial Resistant Streptococcus pneumoniae: Prevalence, Mechanisms, and Clinical Implications. Am J Ther. 2017 May;24(3):e361-e369. doi: 10.1097/MJT.0000000000000551. Review. PubMed PMID: 28430673. 4: Seng P, Amrane S, Million M, Stein A. Old antimicrobials and Gram-positive cocci through the example of infective endocarditis and bone and joint infections. Int J Antimicrob Agents. 2017 May;49(5):558-564. doi: 10.1016/j.ijantimicag.2017.03.004. Epub 2017 Mar 29. Review. PubMed PMID: 28365430. 5: Pichler WJ, Srinoulprasert Y, Yun J, Hausmann O. Multiple Drug Hypersensitivity. Int Arch Allergy Immunol. 2017;172(3):129-138. doi: 10.1159/000458725. Epub 2017 Mar 18. Review. PubMed PMID: 28315874; PubMed Central PMCID: PMC5472211. 6: White PL, Backx M, Barnes RA. Diagnosis and management of Pneumocystis jirovecii infection. Expert Rev Anti Infect Ther. 2017 May;15(5):435-447. doi: 10.1080/14787210.2017.1305887. Epub 2017 Mar 20. Review. PubMed PMID: 28287010. 7: Bienenfeld A, Nagler AR, Orlow SJ. Oral Antibacterial Therapy for Acne Vulgaris: An Evidence-Based Review. Am J Clin Dermatol. 2017 Aug;18(4):469-490. doi: 10.1007/s40257-017-0267-z. Review. PubMed PMID: 28255924. 8: Feldman C, Anderson R, Rossouw T. HIV-related pneumococcal disease prevention in adults. Expert Rev Respir Med. 2017 Mar;11(3):181-199. doi: 10.1080/17476348.2017.1289841. Epub 2017 Feb 21. Review. PubMed PMID: 28228053. 9: Zayyad H, Eliakim-Raz N, Leibovici L, Paul M. Revival of old antibiotics: needs, the state of evidence and expectations. Int J Antimicrob Agents. 2017 May;49(5):536-541. doi: 10.1016/j.ijantimicag.2016.11.021. Epub 2017 Feb 2. Review. PubMed PMID: 28162982. 10: Kaye KS, Gales AC, Dubourg G. Old antibiotics for multidrug-resistant pathogens: from in vitro activity to clinical outcomes. Int J Antimicrob Agents. 2017 May;49(5):542-548. doi: 10.1016/j.ijantimicag.2016.11.020. Epub 2017 Jan 24. Review. PubMed PMID: 28130072. 11: Messiaen PE, Cuyx S, Dejagere T, van der Hilst JC. The role of CD4 cell count as discriminatory measure to guide chemoprophylaxis against Pneumocystis jirovecii pneumonia in human immunodeficiency virus-negative immunocompromised patients: A systematic review. Transpl Infect Dis. 2017 Apr;19(2). doi: 10.1111/tid.12651. Epub 2017 Feb 15. Review. PubMed PMID: 28035717. 12: Biagi F, Biagi GL, Corazza GR. What is the best therapy for Whipple's disease? Our point of view. Scand J Gastroenterol. 2017 Apr;52(4):465-466. doi: 10.1080/00365521.2016.1264009. Epub 2016 Dec 7. Review. PubMed PMID: 27924649. 13: Ishikawa S, Watanabe T, Iino M. Acute septic arthritis of the temporomandibular joint derived from otitis media: a report and review of the English and Japanese literature. Oral Maxillofac Surg. 2017 Mar;21(1):83-85. doi: 10.1007/s10006-016-0604-z. Epub 2016 Dec 5. Review. PubMed PMID: 27917456. 14: Ezzedine K. [What's new in dermatological therapy?]. Ann Dermatol Venereol. 2016 Dec;143 Suppl 3:S37-S42. doi: 10.1016/S0151-9638(18)30048-6. Review. French. PubMed PMID: 29429508. 15: Baker R, Seamon J. BET 1: Trimethoprim-sulfamethoxazole in uncomplicated skin abscess. Emerg Med J. 2016 Dec;33(12):891-892. doi: 10.1136/emermed-2016-206440.1. Review. PubMed PMID: 27864392. 16: Li H, Huang H, He H. Successful treatment of severe Pneumocystis pneumonia in an immunosuppressed patient using caspofungin combined with clindamycin: a case report and literature review. BMC Pulm Med. 2016 Nov 11;16(1):144. Review. PubMed PMID: 27835947; PubMed Central PMCID: PMC5106782. 17: Nakamura I, Nagakura T, Fujita H, Fukusima S, Gonoi T. Nocardia elegans infection: a case report and literature review. Int J Infect Dis. 2017 Jan;54:15-17. doi: 10.1016/j.ijid.2016.10.031. Epub 2016 Nov 5. Review. PubMed PMID: 27826114. 18: Price JR, Guran LA, Gregory WT, McDonagh MS. Nitrofurantoin vs other prophylactic agents in reducing recurrent urinary tract infections in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2016 Nov;215(5):548-560. doi: 10.1016/j.ajog.2016.07.040. Epub 2016 Jul 22. Review. PubMed PMID: 27457111. 19: Hernandez AV, Thota P, Pellegrino D, Pasupuleti V, Benites-Zapata VA, Deshpande A, Penalva de Oliveira AC, Vidal JE. A systematic review and meta-analysis of the relative efficacy and safety of treatment regimens for HIV-associated cerebral toxoplasmosis: is trimethoprim-sulfamethoxazole a real option? HIV Med. 2017 Feb;18(2):115-124. doi: 10.1111/hiv.12402. Epub 2016 Jun 28. Review. PubMed PMID: 27353303. 20: Tattevin P, Mainardi JL. Analysis of the 2015 American and European guidelines for the management of infective endocarditis. Med Mal Infect. 2016 Dec;46(8):406-410. doi: 10.1016/j.medmal.2016.05.008. Epub 2016 Jun 11. Review. PubMed PMID: 27297743.