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MedKoo Cat#: 341123 | Name: Streptothricin F

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Streptothricin F is a biochemical.

Chemical Structure

Streptothricin F
Streptothricin F
CAS#3808-42-2

Theoretical Analysis

MedKoo Cat#: 341123

Name: Streptothricin F

CAS#: 3808-42-2

Chemical Formula: C19H34N8O8

Exact Mass: 502.2500

Molecular Weight: 502.53

Elemental Analysis: C, 45.41; H, 6.82; N, 22.30; O, 25.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Streptothricin F; BRN 6031385.
IUPAC/Chemical Name
2-((O-(Aminocarbonyl)-2-deoxy-2-((3,6-diamino-1-oxohexyl)amino)-beta-D-gulopyranosyl)amino)-1,3,5,6,7,7a-hexahydro-7-hydroxy-4H-imidazo(4,5-c)pyridin-4-one
InChi Key
NRAUADCLPJTGSF-VLSXYIQESA-N
InChi Code
InChI=1S/C19H34N8O8/c20-3-1-2-7(21)4-10(30)24-13-14(31)15(35-18(22)33)9(6-28)34-17(13)27-19-25-11-8(29)5-23-16(32)12(11)26-19/h7-9,11-15,17,28-29,31H,1-6,20-21H2,(H2,22,33)(H,23,32)(H,24,30)(H2,25,26,27)/t7-,8+,9+,11+,12-,13+,14-,15-,17+/m0/s1
SMILES Code
O[C@@H]1CNC(=O)[C@@H]2[C@@H]1NC(N[C@@H]1O[C@@H]([C@@H]([C@H]([C@H]1NC(C[C@H](CCCN)N)=O)O)OC(N)=O)CO)=N2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 502.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chang CY, Lyu SY, Liu YC, Hsu NS, Wu CC, Tang CF, Lin KH, Ho JY, Wu CJ, Tsai MD, Li TL. Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1943-8. doi: 10.1002/anie.201307989. Epub 2014 Jan 21. PubMed PMID: 24505011. 2: Li J, Guo Z, Huang W, Meng X, Ai G, Tang G, Chen Y. Mining of a streptothricin gene cluster from Streptomyces sp. TP-A0356 genome via heterologous expression. Sci China Life Sci. 2013 Jul;56(7):619-27. doi: 10.1007/s11427-013-4504-2. Epub 2013 Jul 6. PubMed PMID: 23832251. 3: Ji Z, Wang M, Wei S, Zhang J, Wu W. Isolation, structure elucidation and antibacterial activities of streptothricin acids. J Antibiot (Tokyo). 2009 May;62(5):233-7. doi: 10.1038/ja.2009.16. Epub 2009 Mar 20. PubMed PMID: 19300469. 4: Viktorov AV, Pleshkov EN, Driniaev VA. [A new HPLC method for determination of main constituents of the streptothricin complex. Analysis of nourseothricin, grisin and kormogrisin]. Antibiot Khimioter. 2006;51(2):8-12. Russian. PubMed PMID: 16878386. 5: Jackson MD, Gould SJ, Zabriskie TM. Studies on the formation and incorporation of streptolidine in the biosynthesis of the peptidyl nucleoside antibiotic streptothricin F. J Org Chem. 2002 May 3;67(9):2934-41. PubMed PMID: 11975549. 6: Zähringer U, Voigt W, Seltmann G. Nourseothricin (streptothricin) inactivated by a plasmid pIE636 encoded acetyl transferase of Escherichia coli: location of the acetyl group. FEMS Microbiol Lett. 1993 Jul 1;110(3):331-4. PubMed PMID: 8394835. 7: Inamori Y, Kubo M, Tsujibo H. The mechanism of delayed insecticidal action of streptothricin antibiotics. III. The mode of delayed insecticidal action of racemomycin-A. Chem Pharm Bull (Tokyo). 1987 Apr;35(4):1509-14. PubMed PMID: 2820598. 8: Khokhlov AS. [Achievements in the study of streptothricin antibiotics]. Antibiotiki. 1983 Aug;28(8):613-22. Russian. PubMed PMID: 6314881. 9: Seidel L, Haupt I. [Isolation of streptothricin resistant mutants from E coli K12, strain A19]. Z Allg Mikrobiol. 1982;22(2):133-7. German. PubMed PMID: 6283749. 10: Liu WC, Astle GL, Wells JS, Cruthers LR, Platt TB, Brown WE, Linkenheimer WH. Separation and biologic activities of individual components of S15-1, a streptothricin class antibiotic. J Antibiot (Tokyo). 1981 Mar;34(3):292-7. PubMed PMID: 6268589. 11: Haupt I, Jonák J, Rychlík I, Thrum H. Action of streptothricin F on ribosomal functions. J Antibiot (Tokyo). 1980 Jun;33(6):636-41. PubMed PMID: 6252135. 12: Haupt I, Hübener R, Thrum H. Streptothricin F, an inhibitor of protein synthesis with miscoding activity. J Antibiot (Tokyo). 1978 Nov;31(11):1137-42. PubMed PMID: 363671. 13: TANIYAMA H, MIYOSHI F, KAGEYAMA K. [Chemical studies on antibiotics produced by actinomycetes. XI. Racemomycin. (8). On racemomycin A, B, and C]. Yakugaku Zasshi. 1962 Jan;82:87-91. Japanese. PubMed PMID: 13919568.