Synonym
Streptothricin E; BRN 4286375.
IUPAC/Chemical Name
2-((O-(Aminocarbonyl)-2-((3-amino-6-((3,6-diamino-1-oxohexyl)amino)-1-oxohexyl)amino)-2-deoxy-beta-D-gulopyranosyl)amino)-1,3a,5,6,7,7a-hexahydro-7-hydroxy-4H-imidazo(4,5-c)pyridin-4-one
InChi Key
SCHKAKNJXBPJHD-SNQQVPMJSA-N
InChi Code
InChI=1S/C25H46N10O9/c26-5-1-3-11(27)7-15(38)30-6-2-4-12(28)8-16(39)32-19-20(40)21(44-24(29)42)14(10-36)43-23(19)35-25-33-17-13(37)9-31-22(41)18(17)34-25/h11-14,17-21,23,36-37,40H,1-10,26-28H2,(H2,29,42)(H,30,38)(H,31,41)(H,32,39)(H2,33,34,35)/t11-,12-,13+,14+,17+,18-,19+,20-,21-,23+/m0/s1
SMILES Code
C1([C@@H]2[C@@H]([C@@H](CN1)O)NC(=N2)N[C@H]1[C@@H]([C@H](O)[C@@H](OC(=O)N)[C@H](O1)CO)NC(C[C@H](CCCNC(C[C@H](CCCN)N)=O)N)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
630.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gan M, Zheng X, Liu Y, Guan Y, Xiao C. Three new 12-carbamoylated streptothricins from Streptomyces sp. I08A 1776. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6151-4. doi: 10.1016/j.bmcl.2012.08.003. Epub 2012 Aug 10. PubMed PMID: 22939698.
2: Gan M, Zheng X, Gan L, Guan Y, Hao X, Liu Y, Si S, Zhang Y, Yu L, Xiao C. Streptothricin derivatives from Streptomyces sp. I08A 1776. J Nat Prod. 2011 May 27;74(5):1142-7. doi: 10.1021/np2000733. Epub 2011 Apr 21. PubMed PMID: 21510638.
3: Miyashiro S, Ando T, Hirayama K, Kida T, Shibai H, Murai A, Shiio T, Udaka S. New streptothricin-group antibiotics, AN-201 I and II. Screening, fermentation, isolation, structure and biological activity. J Antibiot (Tokyo). 1983 Dec;36(12):1638-43. PubMed PMID: 6319345.
4: Khokhlov AS. [Achievements in the study of streptothricin antibiotics]. Antibiotiki. 1983 Aug;28(8):613-22. Russian. PubMed PMID: 6314881.
5: Liu WC, Astle GL, Wells JS, Cruthers LR, Platt TB, Brown WE, Linkenheimer WH. Separation and biologic activities of individual components of S15-1, a streptothricin class antibiotic. J Antibiot (Tokyo). 1981 Mar;34(3):292-7. PubMed PMID: 6268589.
