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MedKoo Cat#: 555181 | Name: PYD-106
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PYD-106 is a GluN2C-selective NMDA receptor positive allosteric modulator.

Chemical Structure

PYD-106
PYD-106
CAS#1560894-05-4

Theoretical Analysis

MedKoo Cat#: 555181

Name: PYD-106

CAS#: 1560894-05-4

Chemical Formula: C25H24N2O5

Exact Mass: 432.1685

Molecular Weight: 432.48

Elemental Analysis: C, 69.43; H, 5.59; N, 6.48; O, 18.50

Price and Availability

Size Price Availability Quantity
1mg USD 230.00 2 Weeks
5mg USD 490.00 2 Weeks
10mg USD 825.00 2 Weeks
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Related CAS #
No Data
Synonym
PYD-106; PYD 106; PYD106.
IUPAC/Chemical Name
Methyl 4-(3-acetyl-4-hydroxy-1-(2-(2-methyl-1H-indol-3-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate
InChi Key
LIFGURQFZLMSDE-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H24N2O5/c1-14-18(19-6-4-5-7-20(19)26-14)12-13-27-22(21(15(2)28)23(29)24(27)30)16-8-10-17(11-9-16)25(31)32-3/h4-11,22,26,29H,12-13H2,1-3H3
SMILES Code
O=C(OC)C1=CC=C(C(C(C(C)=O)=C2O)N(CCC3=C(C)NC4=C3C=CC=C4)C2=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
PYD-106 enhances NR2C subunit-containing NMDA receptor responses in HEK293 cells (EC50 = 13 µM) and selectively targets these receptors over others like NR2A, NR2B, and NR2D.
In vitro activity:
In cultured HEK-293 cells, PYD-106, at a concentration of 30 μM, showed no effects on receptor types such as GluN2A, GluN2B, and GluN2D, as well as AMPA and kainate receptors. When coapplied with glutamate and glycine, PYD-106 at 50 μM significantly enhanced the responses of GluN1/GluN2C NMDA receptors in HEK-293 cells, indicating its positive allosteric modulatory effects. Reference: Mol Pharmacol. 2014 Nov;86(5):548-60. https://pubmed.ncbi.nlm.nih.gov/25205677/
In vivo activity:
To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 432.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Mol Pharmacol. 2014 Nov;86(5):548-60. doi: 10.1124/mol.114.094516. Epub 2014 Sep 9. PMID: 25205677; PMCID: PMC4201136. 2. Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S. Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat Struct Mol Biol. 2023 May;30(5):629-639. doi: 10.1038/s41594-023-00959-z. Epub 2023 Mar 23. PMID: 36959261.
In vitro protocol:
1. Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Mol Pharmacol. 2014 Nov;86(5):548-60. doi: 10.1124/mol.114.094516. Epub 2014 Sep 9. PMID: 25205677; PMCID: PMC4201136. 2. Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S. Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat Struct Mol Biol. 2023 May;30(5):629-639. doi: 10.1038/s41594-023-00959-z. Epub 2023 Mar 23. PMID: 36959261.
In vivo protocol:
To be determined
1: Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S. Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat Struct Mol Biol. 2023 May;30(5):629-639. doi: 10.1038/s41594-023-00959-z. Epub 2023 Mar 23. PMID: 36959261. 2: Bechthold E, Grey L, Diamant E, Schmidt J, Steigerwald R, Zhao F, Hansen KB, Bunch L, Clausen RP, Wünsch B. In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs. Biol Chem. 2022 Nov 25;404(4):255-265. doi: 10.1515/hsz-2022-0229. PMID: 36427206; PMCID: PMC10012426. 3: Chou TH, Kang H, Simorowski N, Traynelis SF, Furukawa H. Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. Mol Cell. 2022 Dec 1;82(23):4548-4563.e4. doi: 10.1016/j.molcel.2022.10.008. Epub 2022 Oct 28. PMID: 36309015; PMCID: PMC9722627. 4: Kaiser TM, Kell SA, Kusumoto H, Shaulsky G, Bhattacharya S, Epplin MP, Strong KL, Miller EJ, Cox BD, Menaldino DS, Liotta DC, Traynelis SF, Burger PB. The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor. Mol Pharmacol. 2018 Feb;93(2):141-156. doi: 10.1124/mol.117.110940. Epub 2017 Dec 14. PMID: 29242355; PMCID: PMC5767683. 5: Hackos DH, Hanson JE. Diverse modes of NMDA receptor positive allosteric modulation: Mechanisms and consequences. Neuropharmacology. 2017 Jan;112(Pt A):34-45. doi: 10.1016/j.neuropharm.2016.07.037. Epub 2016 Jul 30. PMID: 27484578. 6: Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Mol Pharmacol. 2014 Nov;86(5):548-60. doi: 10.1124/mol.114.094516. Epub 2014 Sep 9. PMID: 25205677; PMCID: PMC4201136.