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MedKoo Cat#: 562202 | Name: Tiemonium iodide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tiemonium iodide is a muscarinic receptor antagonist, an anticholinergic, and a parasympatholytic.

Chemical Structure

Tiemonium iodide
Tiemonium iodide
CAS#6252-92-2

Theoretical Analysis

MedKoo Cat#: 562202

Name: Tiemonium iodide

CAS#: 6252-92-2

Chemical Formula: C18H24INO2S

Exact Mass: 445.0572

Molecular Weight: 445.35

Elemental Analysis: C, 48.54; H, 5.43; I, 28.49; N, 3.15; O, 7.18; S, 7.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Tiemonium iodide; Visceralgine; Visceralgin; Tiemozyl; Cerfa 114; Cerfa-114; Cerfa114;
IUPAC/Chemical Name
3-(4-Methylmorpholin-4-ium-4-yl)-1-phenyl-1-thiophen-2-ylpropan-1-ol iodide
InChi Key
IOFXEUZPIIUQAG-UHFFFAOYSA-M
InChi Code
InChI=1S/C18H24NO2S.HI/c1-19(11-13-21-14-12-19)10-9-18(20,17-8-5-15-22-17)16-6-3-2-4-7-16;/h2-8,15,20H,9-14H2,1H3;1H/q+1;/p-1
SMILES Code
OC(C1=CC=CS1)(C2=CC=CC=C2)CC[N+]3(C)CCOCC3.[I-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 445.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shang Y, Zhang X, Chen L, Leng W, Lei X, Yang Q, Liang Z, Wang J. Assessment of Left Ventricular Structural Remodelling in Patients with Diabetic Cardiomyopathy by Cardiovascular Magnetic Resonance. J Diabetes Res. 2016;2016:4786925. doi: 10.1155/2016/4786925. Epub 2016 Jun 22. PubMed PMID: 27419144; PubMed Central PMCID: PMC4933864. 2: Guo Y, Liu C, Hu L, Wang X, Alam M, Wang H. An economic method to build a puffing instrument for drug application in vitro. J Neurosci Methods. 2015 Dec 30;256:122-6. doi: 10.1016/j.jneumeth.2015.08.032. Epub 2015 Sep 4. PubMed PMID: 26343324. 3: Biradar DB, Zhou S, Gau HM. Direct asymmetric catalytic thienylaluminum addition to ketones: a concise approach to the synthesis of (S)-tiemonium iodide. Org Lett. 2009 Aug 6;11(15):3386-9. doi: 10.1021/ol901193q. PubMed PMID: 19588914. 4: Klouz A, Zaïem A, Trabelsi S, Loueslati MH, Lakhal M, Belkahia C. Orofacial dyskinesia associated with tiemonium. Fundam Clin Pharmacol. 2007 Dec;21(6):657-8. PubMed PMID: 18034667. 5: Borron SW, Scherrmann JM, Baud FJ. Markedly altered colchicine kinetics in a fatal intoxication: examination of contributing factors. Hum Exp Toxicol. 1996 Nov;15(11):885-90. PubMed PMID: 8938483. 6: Moneret-Vautrin DA, Motin J, Mata E, Guéant JL, Kanny G, Widmer S, Laxenaire MC. Preventing muscle relaxant anaphylaxis with monovalent haptens. A preliminary study. Ann Fr Anesth Reanim. 1993;12(2):190-202. PubMed PMID: 7690205. 7: Gervais C, Lange P. [Visceralgine]. Soins Gynecol Obstet Pueric Pediatr. 1985 Apr;(47):I-II. French. PubMed PMID: 3848153. 8: Okada K, Imai H, Togawa Y, Nagaoka S, Nozaki M, Tsurumi K, Fujimura H. [Effect of tiemonium iodide on colonic motility in dogs]. Nihon Yakurigaku Zasshi. 1982 Dec;80(6):495-503. Japanese. PubMed PMID: 6962171. 9: Gervais C, Lange P. [Visceralgine]. Soins. 1982 Jun;27(383):41-2. French. PubMed PMID: 6923511. 10: Tacke R, Zimonyi-Hegedüs E, Strecker M. [Sila-drugs, XX: Sila-analogue of tiemonium iodide (author's transl)]. Arch Pharm (Weinheim). 1980 Jun;313(6):515-26. German. PubMed PMID: 7406667. 11: Scoular IT, Monks A, Burgess C, Turner P. Human studies on the bioavailability of a quaternary ammonium compounds, tiemonium iodide and tiemonium methosulphate. Curr Med Res Opin. 1976-1977;4(10):732-8. PubMed PMID: 1052164. 12: Oka N, Washida H. [Effect of tiemonium iodide (Visceralgine) on the ureteral contractile activities and its clinical use in urology]. Hinyokika Kiyo. 1970 Oct;16(10):608-18. Japanese. PubMed PMID: 4097819. 13: Pennefather JN, McCulloch MW, Czechowicz S, Pun LQ, Rush M, Rand MJ. Studies with tiemonium iodide. An antispasmodic drug. Arch Int Pharmacodyn Ther. 1968 Jul;174(1):152-66. PubMed PMID: 4386710. 14: Beau G, Constantin M, Talvard J, Duchene-Marullaz P. [Elimination of radioactive tiemonium iodide and research on its metabolites in rats and mice]. Therapie. 1968 Mar-Apr;23(2):399-409. French. PubMed PMID: 5701514. 15: Neveu J. [Tiemonium iodide-novamin sulfone combination in treatment of pain in urology]. J Urol Nephrol (Paris). 1967 Jun;73(6):482-3. French. PubMed PMID: 5634167. 16: PRANDI D, SUREAU C. [OBSTETRICAL STUDY OF A SYNTHETIC SPASMOLYTIC: THIENYLETHYLMORPHOLYLCARBINOL IODIDE (114 TE) (VISCERALGINE)]. Maternite. 1964 Apr;13:119-25. French. PubMed PMID: 14170774.

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