MedKoo Cat#: 562200 | Name: APX001

Description:

WARNING: This product is for research use only, not for human or veterinary use.

APX001 is a prodrug of APX-001A, the first-in-class inhibitor of the fungal protein Gwt1.

Chemical Structure

APX001
CAS#1169701-00-1

Theoretical Analysis

MedKoo Cat#: 562200

Name: APX001

CAS#: 1169701-00-1

Chemical Formula: C22H21N4O6P

Exact Mass: 468.1199

Molecular Weight: 468.40

Elemental Analysis: C, 56.41; H, 4.52; N, 11.96; O, 20.49; P, 6.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
APX001; APX-001; APX 001;
IUPAC/Chemical Name
(2-amino-3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-1-ium-1-yl)methyl hydrogen phosphate
InChi Key
JQONJQKKVAHONF-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H21N4O6P/c23-22-19(4-3-11-26(22)15-31-33(27,28)29)20-13-18(25-32-20)12-16-6-8-17(9-7-16)14-30-21-5-1-2-10-24-21/h1-11,13,23H,12,14-15H2,(H2,27,28,29)
SMILES Code
NC1=[N+](COP([O-])(O)=O)C=CC=C1C2=CC(CC(C=C3)=CC=C3COC4=CC=CC=N4)=NO2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 468.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhao M, Lepak AJ, VanScoy B, Bader JC, Marchillo K, Vanhecker J, Ambrose PG, Andes DR. In Vivo Pharmacokinetics and Pharmacodynamics of APX001 against Candida spp. in a Neutropenic Disseminated Candidiasis Mouse Model. Antimicrob Agents Chemother. 2018 Jan 29. pii: AAC.02542-17. doi: 10.1128/AAC.02542-17. [Epub ahead of print] PubMed PMID: 29378706. 2: Hager CL, Larkin EL, Long L, Zohra Abidi F, Shaw KJ, Ghannoum MA. In Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A/APX001 against Candida auris. Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02319-17. doi: 10.1128/AAC.02319-17. Print 2018 Mar. PubMed PMID: 29311065. 3: Gonzalez-Lara MF, Sifuentes-Osornio J, Ostrosky-Zeichner L. Drugs in Clinical Development for Fungal Infections. Drugs. 2017 Sep;77(14):1505-1518. doi: 10.1007/s40265-017-0805-2. PubMed PMID: 28840541. 4: Osherov N, Kontoyiannis DP. The anti-Aspergillus drug pipeline: Is the glass half full or empty? Med Mycol. 2017 Jan 1;55(1):118-124. Epub 2016 Aug 25. Review. PubMed PMID: 27562862.