MedKoo Cat#: 562193 | Name: VU041

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU041 is an Inwardly Rectifying Potassium (Kir) channel inhibitor. It acts as a mosquitocide, and induces toxicity through neurological poisoning in addition to inducing Malpighian tubule failure that leads to toxicity by an inability to perform osmoregulatory action.

Chemical Structure

VU041
VU041
CAS#332943-64-3

Theoretical Analysis

MedKoo Cat#: 562193

Name: VU041

CAS#: 332943-64-3

Chemical Formula: C19H20F3N3O

Exact Mass: 363.1558

Molecular Weight: 363.38

Elemental Analysis: C, 62.80; H, 5.55; F, 15.68; N, 11.56; O, 4.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
VU041; VU-041; VU 041;
IUPAC/Chemical Name
1-(3,4-Dihydroquinolin-1(2H)-yl)-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)ethan-1-one
InChi Key
DLAGRCZUELSZFG-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20F3N3O/c20-19(21,22)18-14-8-2-4-10-16(14)25(23-18)12-17(26)24-11-5-7-13-6-1-3-9-15(13)24/h1,3,6,9H,2,4-5,7-8,10-12H2
SMILES Code
O=C(N1CCCC2=C1C=CC=C2)CN3N=C(C(F)(F)F)C4=C3CCCC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 363.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Swale DR, Li Z, Guerrero F, Pérez De León AA, Foil LD. Role of inward rectifier potassium channels in salivary gland function and sugar feeding of the fruit fly, Drosophila melanogaster. Pestic Biochem Physiol. 2017 Sep;141:41-49. doi: 10.1016/j.pestbp.2016.11.005. Epub 2016 Nov 15. PubMed PMID: 28911739. 2: Swale DR, Engers DW, Bollinger SR, Gross A, Inocente EA, Days E, Kanga F, Johnson RM, Yang L, Bloomquist JR, Hopkins CR, Piermarini PM, Denton JS. An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria. Sci Rep. 2016 Nov 16;6:36954. doi: 10.1038/srep36954. PubMed PMID: 27849039; PubMed Central PMCID: PMC5111108.