MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 341102 | Name: Molinate
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Molinate is a biochemical.

Chemical Structure

Molinate
Molinate
CAS#2212-67-1

Theoretical Analysis

MedKoo Cat#: 341102

Name: Molinate

CAS#: 2212-67-1

Chemical Formula: C9H17NOS

Exact Mass: 187.1031

Molecular Weight: 187.30

Elemental Analysis: C, 57.71; H, 9.15; N, 7.48; O, 8.54; S, 17.12

Price and Availability

Size Price Availability Quantity
100mg USD 210.00
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Molinate; R-4572 ; R 4572; R4572; Yulan
IUPAC/Chemical Name
1H-Azepine-1-carbothioic acid, hexahydro-, S-ethyl ester
InChi Key
DEDOPGXGGQYYMW-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H17NOS/c1-2-12-9(11)10-7-5-3-4-6-8-10/h2-8H2,1H3
SMILES Code
N1(C(SCC)=O)CCCCCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Molinate is a biochemical.
In vitro activity:
TBD
In vivo activity:
Rats dosed with molinate either as a single large oral dose of 100 mg/kg or as multiple doses of 50 mg/kg for 7 days produced inhibition of brain acetylcholinesterase (AChE). Reference: Toxicol Res (Camb). 2020 Aug 28;9(5):591-600. https://pubmed.ncbi.nlm.nih.gov/33178419/

Preparing Stock Solutions

The following data is based on the product molecular weight 187.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Lock EA. Inhibition of rat brain and human red cell acetylcholinesterase by thiocarbamate herbicides. Toxicol Res (Camb). 2020 Aug 28;9(5):591-600. doi: 10.1093/toxres/tfaa057. PMID: 33178419; PMCID: PMC7640918. 2. Zuno-Floriano FG, Holstege D, Hengel MJ, Gaikwad NW, Aldana-Madrid ML, Miller MG. Determination of vitamin A and its metabolites in rat testis: possible involvement of vitamin A in testicular toxicity caused by molinate. Bull Environ Contam Toxicol. 2012 Jun;88(6):1038-42. doi: 10.1007/s00128-012-0612-0. Epub 2012 Mar 29. PMID: 22456730; PMCID: PMC3339053.
In vitro protocol:
TBD
In vivo protocol:
1. Lock EA. Inhibition of rat brain and human red cell acetylcholinesterase by thiocarbamate herbicides. Toxicol Res (Camb). 2020 Aug 28;9(5):591-600. doi: 10.1093/toxres/tfaa057. PMID: 33178419; PMCID: PMC7640918. 2. Zuno-Floriano FG, Holstege D, Hengel MJ, Gaikwad NW, Aldana-Madrid ML, Miller MG. Determination of vitamin A and its metabolites in rat testis: possible involvement of vitamin A in testicular toxicity caused by molinate. Bull Environ Contam Toxicol. 2012 Jun;88(6):1038-42. doi: 10.1007/s00128-012-0612-0. Epub 2012 Mar 29. PMID: 22456730; PMCID: PMC3339053.
1: Lee YH, Kang HM, Kim MS, Lee JS, Jeong CB, Lee JS. The protective role of multixenobiotic resistance (MXR)-mediated ATP-binding cassette (ABC) transporters in biocides-exposed rotifer Brachionus koreanus. Aquat Toxicol. 2018 Feb;195:129-136. doi: 10.1016/j.aquatox.2017.12.016. Epub 2017 Dec 30. PubMed PMID: 29306793. 2: Suemizu H, Kawai K, Murayama N, Nakamura M, Yamazaki H. Chimeric mice with humanized liver as a model for testing organophosphate and carbamate pesticide exposure. Pest Manag Sci. 2017 Dec 13. doi: 10.1002/ps.4825. [Epub ahead of print] PubMed PMID: 29235720. 3: Haggard DE, Karmaus AL, Martin MT, Judson RS, Setzer RW, Paul Friedman K. High-throughput H295R steroidogenesis assay: utility as an alternative and a statistical approach to characterize effects on steroidogenesis. Toxicol Sci. 2017 Dec 1. doi: 10.1093/toxsci/kfx274. [Epub ahead of print] PubMed PMID: 29216406. 4: Polat A, Polat S, Simsek A, Kurt TT, Ozyurt G. Pesticide residues in muscles of some marine fish species and seaweeds of Iskenderun Bay (Northeastern Mediterranean), Turkey. Environ Sci Pollut Res Int. 2018 Feb;25(4):3756-3764. doi: 10.1007/s11356-017-0756-x. Epub 2017 Nov 22. PubMed PMID: 29168137. 5: Estevinho BN, Lopes AR, Sousa V, Rocha F, Nunes OC. Microencapsulation of Gulosibacter molinativorax ON4(T) cells by a spray-drying process using different biopolymers. J Hazard Mater. 2017 Sep 15;338:85-92. doi: 10.1016/j.jhazmat.2017.05.018. Epub 2017 May 11. PubMed PMID: 28531662. 6: Stipaničev D, Dragun Z, Repec S, Rebok K, Jordanova M. Broad spectrum screening of 463 organic contaminants in rivers in Macedonia. Ecotoxicol Environ Saf. 2017 Jan;135:48-59. doi: 10.1016/j.ecoenv.2016.09.004. Epub 2016 Sep 27. PubMed PMID: 27685670. 7: Thomas ML, de Antueno R, Coyle KM, Sultan M, Cruickshank BM, Giacomantonio MA, Giacomantonio CA, Duncan R, Marcato P. Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3. Mol Oncol. 2016 Nov;10(9):1485-1496. doi: 10.1016/j.molonc.2016.08.004. Epub 2016 Aug 25. PubMed PMID: 27592281; PubMed Central PMCID: PMC5423215. 8: Piscitelli A, Pennacchio A, Longobardi S, Velotta R, Giardina P. Vmh2 hydrophobin as a tool for the development of "self-immobilizing" enzymes for biosensing. Biotechnol Bioeng. 2017 Jan;114(1):46-52. doi: 10.1002/bit.26049. Epub 2016 Jul 26. PubMed PMID: 27427236. 9: Lopes AR, Sousa VM, Estevinho BN, Leite JP, Moreira NFF, Gales L, Rocha F, Nunes OC. Production of microparticles of molinate degrading biocatalysts using the spray drying technique. Chemosphere. 2016 Oct;161:61-68. doi: 10.1016/j.chemosphere.2016.07.006. Epub 2016 Jul 13. PubMed PMID: 27421102. 10: Aleshnya VV, Zhuravlev PV, Panasovets OP. [study in the experimental conditions of pesticide action on microorganisms characterizing sanitary-epidemiological safety of reservoirs]. Gig Sanit. 2016;95(8):785-9. Russian. PubMed PMID: 29430908. 11: Silva E, Daam MA, Cerejeira MJ. Aquatic risk assessment of priority and other river basin specific pesticides in surface waters of Mediterranean river basins. Chemosphere. 2015 Sep;135:394-402. doi: 10.1016/j.chemosphere.2015.05.013. Epub 2015 May 22. PubMed PMID: 26002046. 12: Leite JP, Duarte M, Paiva AM, Ferreira-da-Silva F, Matias PM, Nunes OC, Gales L. Structure-guided engineering of molinate hydrolase for the degradation of thiocarbamate pesticides. PLoS One. 2015 Apr 23;10(4):e0123430. doi: 10.1371/journal.pone.0123430. eCollection 2015. PubMed PMID: 25905461; PubMed Central PMCID: PMC4407906. 13: Aburai N, Abe K. Metabolic switching: synergistic induction of carotenogenesis in the aerial microalga, Vischeria helvetica, under environmental stress conditions by inhibitors of fatty acid biosynthesis. Biotechnol Lett. 2015 May;37(5):1073-80. doi: 10.1007/s10529-015-1770-z. Epub 2015 Mar 28. PubMed PMID: 25820338. 14: Papadakis EN, Vryzas Z, Kotopoulou A, Kintzikoglou K, Makris KC, Papadopoulou-Mourkidou E. A pesticide monitoring survey in rivers and lakes of northern Greece and its human and ecotoxicological risk assessment. Ecotoxicol Environ Saf. 2015 Jun;116:1-9. doi: 10.1016/j.ecoenv.2015.02.033. Epub 2015 Feb 28. PubMed PMID: 25733189. 15: Sugrue E, Fraser NJ, Hopkins DH, Carr PD, Khurana JL, Oakeshott JG, Scott C, Jackson CJ. Evolutionary expansion of the amidohydrolase superfamily in bacteria in response to the synthetic compounds molinate and diuron. Appl Environ Microbiol. 2015 Apr;81(7):2612-24. doi: 10.1128/AEM.04016-14. Epub 2015 Jan 30. PubMed PMID: 25636851; PubMed Central PMCID: PMC4357960. 16: Lee JW, Kim BM, Jeong CB, Won EJ, Rhee JS, Lee JS. Inhibitory effects of biocides on transcription and protein activity of acetylcholinesterase in the intertidal copepod Tigriopus japonicus. Comp Biochem Physiol C Toxicol Pharmacol. 2015 Jan;167:147-56. PubMed PMID: 25468639. 17: Kim BM, Lee JW, Seo JS, Shin KH, Rhee JS, Lee JS. Modulated expression and enzymatic activity of the monogonont rotifer Brachionus koreanus Cu/Zn- and Mn-superoxide dismutase (SOD) in response to environmental biocides. Chemosphere. 2015 Feb;120:470-8. doi: 10.1016/j.chemosphere.2014.08.042. Epub 2014 Sep 26. PubMed PMID: 25260044. 18: Kim HG, Yeon SM, Kim KH, Kim H, Park JI, Kang HJ, Cha EJ, Park HD, Kang HJ, Park TW, Jeon YH, Park YI, Chang KT, Jung YW. Estrogenic endocrine-disrupting chemicals modulate the production of inflammatory mediators and cell viability of lipopolysaccharide-stimulated macrophages. Inflammation. 2015 Apr;38(2):595-605. doi: 10.1007/s10753-014-9966-2. PubMed PMID: 25059213. 19: Yamashita M, Suemizu H, Murayama N, Nishiyama S, Shimizu M, Yamazaki H. Human plasma concentrations of herbicidal carbamate molinate extrapolated from the pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. Regul Toxicol Pharmacol. 2014 Oct;70(1):214-21. doi: 10.1016/j.yrtph.2014.06.028. Epub 2014 Jul 10. PubMed PMID: 25016177. 20: Gomes HI, Fan G, Mateus EP, Dias-Ferreira C, Ribeiro AB. Assessment of combined electro-nanoremediation of molinate contaminated soil. Sci Total Environ. 2014 Sep 15;493:178-84. doi: 10.1016/j.scitotenv.2014.05.112. Epub 2014 Jun 17. PubMed PMID: 24946031.