MedKoo Cat#: 562165 | Name: TPCK
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TPCK is a non-specific irreversible inhibitor of serine/cysteine proteases. It acts by inhibiting ScRce1 in the presence of a Ras reporter, but not in the presence of the a-factor peptide.

Chemical Structure

TPCK
TPCK
CAS#402-71-1

Theoretical Analysis

MedKoo Cat#: 562165

Name: TPCK

CAS#: 402-71-1

Chemical Formula: C17H18ClNO3S

Exact Mass: 351.0696

Molecular Weight: 351.84

Elemental Analysis: C, 58.03; H, 5.16; Cl, 10.08; N, 3.98; O, 13.64; S, 9.11

Price and Availability

Size Price Availability Quantity
100mg USD 190.00
250mg USD 300.00
1g USD 620.00
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Related CAS #
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Synonym
TPCK; Tos-Phe-CH2Cl;
IUPAC/Chemical Name
(S)-N-(4-chloro-3-oxo-1-phenylbutan-2-yl)-4-methylbenzenesulfonamide
InChi Key
MQUQNUAYKLCRME-INIZCTEOSA-N
InChi Code
InChI=1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1
SMILES Code
O=S(N[C@@H](CC1=CC=CC=C1)C(CCl)=O)(C2=CC=C(C)C=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pauly PC, Klein C. An uncleaved glycosylphosphatidylinositol signal mediates Ca(2+)-sensitive protein degradation. Biochem J. 1996 Jul 15;317 ( Pt 2):533-40. PubMed PMID: 8713082; PubMed Central PMCID: PMC1217519. 2: Mizuguchi J, Utsunomiya N, Nakanishi M, Arata Y, Fukazawa H. Differential sensitivity of anti-IgM-induced and NaF-induced inositol phospholipid metabolism to serine protease inhibitors in BAL17 B lymphoma cells. Biochem J. 1989 Nov 1;263(3):641-6. PubMed PMID: 2557005; PubMed Central PMCID: PMC1133481. 3: Braun NJ, Schnebli HP. Interaction of Eglin c with polymorphonuclear cells: evidence for binding to the cell surface. Biol Chem Hoppe Seyler. 1987 Feb;368(2):155-61. PubMed PMID: 3566916. 4: Hubbard JR, Barrett A, Kalimi M. Influence of proteinase inhibitors on glucocorticoid receptor binding. Biochim Biophys Acta. 1984 Apr 10;798(2):187-91. PubMed PMID: 6712987. 5: Da Graça M, Mazzacoratti N, Sampaio CA. Rat liver kininase, a serine peptidase. Biochem Pharmacol. 1982 Mar 1;31(5):799-804. PubMed PMID: 7044380. 6: Ahkong QF, Botham GM, Woodward AW, Lucy JA. Calcium-activated thiol-proteinase activity in the fusion of rat erythrocytes induced by benzyl alcohol. Biochem J. 1980 Dec 15;192(3):829-36. PubMed PMID: 7016117; PubMed Central PMCID: PMC1162406. 7: Buse G, Klostermeyer H, Steffens G. Transpeptidation in sequence analysis. Investigations concerning a native and a synthetic hexapeptide. Hoppe Seylers Z Physiol Chem. 1975 Jun;356(6):895-902. PubMed PMID: 1181281.