MedKoo Cat#: 562160 | Name: Danthron
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Danthron, also known as Chrysazine, Chrysazin, Dantron, and Antrapurol, is an inhibitor of HO-1/CPR BRET signal. It acts by significantly reducing BRETmax from cells coexpressing CPR-GFP and Luc-HO-1.

Chemical Structure

Danthron
Danthron
CAS#117-10-2

Theoretical Analysis

MedKoo Cat#: 562160

Name: Danthron

CAS#: 117-10-2

Chemical Formula: C14H8O4

Exact Mass: 240.0423

Molecular Weight: 240.21

Elemental Analysis: C, 70.00; H, 3.36; O, 26.64

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
10g USD 400.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Danthron; Chrysazin; Dantron; Antrapurol; Chrysazine; 1,8-Dihydroxyanthraquinone; Istizine; 1,8-DHAQ; Altan;
IUPAC/Chemical Name
1,8-Dihydroxyanthraquinone
InChi Key
QBPFLULOKWLNNW-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H8O4/c15-9-5-1-3-7-11(9)14(18)12-8(13(7)17)4-2-6-10(12)16/h1-6,15-16H
SMILES Code
O=C(C1=C2C(O)=CC=C1)C3=CC=CC(O)=C3C2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 240.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Candy B, Jones L, Larkin PJ, Vickerstaff V, Tookman A, Stone P. Laxatives for the management of constipation in people receiving palliative care. Cochrane Database Syst Rev. 2015 May 13;(5):CD003448. doi: 10.1002/14651858.CD003448.pub4. Review. PubMed PMID: 25967924. 2: Candy B, Jones L, Goodman ML, Drake R, Tookman A. Laxatives or methylnaltrexone for the management of constipation in palliative care patients. Cochrane Database Syst Rev. 2011 Jan 19;(1):CD003448. doi: 10.1002/14651858.CD003448.pub3. Review. Update in: Cochrane Database Syst Rev. 2015;5:CD003448. PubMed PMID: 21249653. 3: Miles CL, Fellowes D, Goodman ML, Wilkinson S. Laxatives for the management of constipation in palliative care patients. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003448. Review. Update in: Cochrane Database Syst Rev. 2011;(1):CD003448. PubMed PMID: 17054172. 4: Xing JH, Soffer EE. Adverse effects of laxatives. Dis Colon Rectum. 2001 Aug;44(8):1201-9. Review. PubMed PMID: 11535863. 5: Müller L, Kasper P. OTC pharmaceuticals and genotoxicity testing: the paracetamol, anthraquinone, and griseofulvin cases. Arch Toxicol Suppl. 1995;17:312-25. Review. PubMed PMID: 7786168. 6: Gattuso JM, Kamm MA. Adverse effects of drugs used in the management of constipation and diarrhoea. Drug Saf. 1994 Jan;10(1):47-65. Review. PubMed PMID: 8136086. 7: Dantron (chrysazin; 1,8-dihydroxyanthraquinone). IARC Monogr Eval Carcinog Risks Hum. 1990;50:265-75. Review. Erratum in: IARC Monogr Eval Carcinog Risks Hum 1994;59:257. PubMed PMID: 2292802. 8: Laxatives: replacing danthron. Drug Ther Bull. 1988 Jul 11;26(14):53-6. Review. PubMed PMID: 3042346.