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MedKoo Cat#: 562152 | Name: LB-205

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LB-205 is a Zn 2+ dependent pan-inhibitor of class I and class II HDACs with a long half-life in vivo.

Chemical Structure

LB-205
LB-205
CAS#1113025-86-7

Theoretical Analysis

MedKoo Cat#: 562152

Name: LB-205

CAS#: 1113025-86-7

Chemical Formula: C19H22N2O2S

Exact Mass: 342.1402

Molecular Weight: 342.45

Elemental Analysis: C, 66.64; H, 6.48; N, 8.18; O, 9.34; S, 9.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LB-205; LB 205; LB205;
IUPAC/Chemical Name
2-Mercapto-N-[6-oxo-6-(phenylamino)hexyl]-benzamide
InChi Key
DLAHPFVJAZCDGF-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H22N2O2S/c22-18(21-15-9-3-1-4-10-15)13-5-2-8-14-20-19(23)16-11-6-7-12-17(16)24/h1,3-4,6-7,9-12,24H,2,5,8,13-14H2,(H,20,23)(H,21,22)
SMILES Code
O=C(NCCCCCC(NC1=CC=CC=C1)=O)C2=CC=CC=C2S
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 342.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lu J, Frerich JM, Turtzo LC, Li S, Chiang J, Yang C, Wang X, Zhang C, Wu C, Sun Z, Niu G, Zhuang Z, Brady RO, Chen X. Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52. doi: 10.1073/pnas.1308950110. Epub 2013 Jun 10. PubMed PMID: 23754423; PubMed Central PMCID: PMC3696796. 2: Lu J, Yang C, Chen M, Ye DY, Lonser RR, Brady RO, Zhuang Z. Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21200-5. doi: 10.1073/pnas.1119181109. Epub 2011 Dec 12. PubMed PMID: 22160715; PubMed Central PMCID: PMC3248545.