KSP-IA | CAS#639074-49-0 | KSP inhibitor

MedKoo Cat#: 558239 | Name: KSP-IA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KSP-IA is a potent, specific, allosteric and cell-active inhibitor of KSP.

Chemical Structure

KSP-IA

CAS#639074-49-0

Theoretical Analysis

MedKoo Cat#: 558239

Name: KSP-IA

CAS#: 639074-49-0

Chemical Formula: C21H22F2N2O

Exact Mass: 356.1700

Molecular Weight: 356.41

Elemental Analysis: C, 70.77; H, 6.22; F, 10.66; N, 7.86; O, 4.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KSP-IA; KSP IA; KSPIA;

IUPAC/Chemical Name

(S)-2-Amino-1-((S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl)-3-methylbutan-1-one

InChi Key

GNFWJCGIZJCASB-PMACEKPBSA-N

InChi Code

InChI=1S/C21H22F2N2O/c1-13(2)20(24)21(26)25-12-15(17-11-16(22)8-9-18(17)23)10-19(25)14-6-4-3-5-7-14/h3-11,13,19-20H,12,24H2,1-2H3/t19-,20-/m0/s1

SMILES Code

CC(C)[C@H](N)C(N1[C@H](C2=CC=CC=C2)C=C(C3=CC(F)=CC=C3F)C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 356.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tao W, South VJ, Zhang Y, Davide JP, Farrell L, Kohl NE, Sepp-Lorenzino L, Lobell RB. Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage. Cancer Cell. 2005 Jul;8(1):49-59. PubMed PMID: 16023598.