MedKoo Cat#: 562124 | Name: LIMK-IN-22j

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LIMK-IN-22j is a potent and selective LIMK inhibitor.

Chemical Structure

LIMK-IN-22j
LIMK-IN-22j
CAS#1116571-01-7

Theoretical Analysis

MedKoo Cat#: 562124

Name: LIMK-IN-22j

CAS#: 1116571-01-7

Chemical Formula: C20H21BrN8

Exact Mass: 452.1073

Molecular Weight: 453.34

Elemental Analysis: C, 52.99; H, 4.67; Br, 17.63; N, 24.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
LIMK-IN-22j; LIMK IN 22j; LIMKIN22j; LIMK inhibitor 22j; LIMK inhibitor-22j;
IUPAC/Chemical Name
(S,Z)-N-(3-Bromophenyl)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide
InChi Key
KSECQYDNQYAZMQ-AWEZNQCLSA-N
InChi Code
InChI=1S/C20H21BrN8/c1-13-9-23-18-17(13)19(26-12-25-18)28-6-7-29(14(2)10-28)20(24-11-22)27-16-5-3-4-15(21)8-16/h3-5,8-9,12,14H,6-7,10H2,1-2H3,(H,24,27)(H,23,25,26)/t14-/m0/s1
SMILES Code
CC1=CNC2=NC=NC(N3C[C@H](C)N(/C(NC4=CC=CC(Br)=C4)=N\C#N)CC3)=C21
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 453.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wu J, Liu S, Fan Z, Zhang L, Tian Y, Yang R. A novel and selective inhibitor of PKC ζ potently inhibits human breast cancer metastasis in vitro and in mice. Tumour Biol. 2016 Jun;37(6):8391-401. doi: 10.1007/s13277-015-4744-9. Epub 2016 Jan 5. PubMed PMID: 26733166. 2: Kremer D, Heinen A, Jadasz J, Göttle P, Zimmermann K, Zickler P, Jander S, Hartung HP, Küry P. p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9087-92. doi: 10.1073/pnas.0900204106. Epub 2009 May 19. PubMed PMID: 19458044; PubMed Central PMCID: PMC2690052.