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MedKoo Cat#: 581072 | Name: Alilusem

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alilusem is a novel diuretic, it possesses beneficial properties for the clinical treatment of hypertension. Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells, OATP-B plays a major role in the uptake of the novel loop diuretic M17055 from apical membranes in Caco-2 cells.

Chemical Structure

Alilusem
Alilusem
CAS#114417-20-8 (potassium)

Theoretical Analysis

MedKoo Cat#: 581072

Name: Alilusem

CAS#: 114417-20-8 (potassium)

Chemical Formula: C17H15ClN2O5S

Exact Mass: 394.0390

Molecular Weight: 394.83

Elemental Analysis: C, 51.72; H, 3.83; Cl, 8.98; N, 7.10; O, 20.26; S, 8.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
791024-52-7 (free base)
Synonym
Alilusem; Alilusem potassium; M 17055; D09772; M17055;
IUPAC/Chemical Name
7-Chloro-1-(2-methylbenzoyl)-2,3-dihydroquinolin-4(1H)-one (E)-O-sulfooxime
InChi Key
QQCSUWGQBREWRO-XDJHFCHBSA-N
InChi Code
InChI=1S/C17H15ClN2O5S/c1-11-4-2-3-5-13(11)17(21)20-9-8-15(19-25-26(22,23)24)14-7-6-12(18)10-16(14)20/h2-7,10H,8-9H2,1H3,(H,22,23,24)/b19-15+
SMILES Code
O=C(N1CC/C(C2=C1C=C(Cl)C=C2)=N\OS(O)(=O)=O)C3=CC=CC=C3C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 394.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nishimura T, Kubo Y, Kato Y, Sai Y, Ogihara T, Tsuji A. Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells: involvement of organic anion transporting polypeptide (OATP)-B. Pharm Res. 2007 Jan;24(1):90-8. Epub 2006 Nov 14. PubMed PMID: 17103337. 2: Nishimura T, Kato Y, Sai Y, Ogihara T, Tsuji A. Characterization of renal excretion mechanism for a novel diuretic, M17055, in rats. J Pharm Sci. 2004 Oct;93(10):2558-66. PubMed PMID: 15349965. 3: Nakajima H, Nakanishi T, Naba H, Nakai K, Matsumoto S, Nagasawa K, Ida K, Ogihara T, Ohzawa N. Studies on the metabolic fate of M17055, a novel diuretic (6). Assessment for drug-drug interactions of M17055 in metabolism, distribution and excretion. Xenobiotica. 2002 Dec;32(12):1161-72. PubMed PMID: 12593763. 4: Kim S, Hamaguchi A, Shinkawa T, Kato Y, Tsuchiya N, Miura K, Ohta K, Iwao H. Molecular effects of M17055, furosemide and thiazide on cardiac hypertrophy of spontaneously hypertensive rats. J Pharmacol Exp Ther. 1996 Nov;279(2):983-90. PubMed PMID: 8930208. 5: Shinkawa T, Kato Y, Tsuchiya N, Yamasaki F, Uemura A, Mizota M. Beneficial effect of a novel diuretic, M17055, on blood pressure and cardiovascular hypertrophy in spontaneously hypertensive rats. Jpn J Pharmacol. 1993 Oct;63(2):241-9. PubMed PMID: 8283835. 6: Yamasaki F, Yoshitomi K, Shinkawa T, Imai M. Effects of amiloride and a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone-4-oxime-o-su lfonic acid, potassium salt (M17055), on calcium transport in the rabbit connecting tubule. J Pharmacol Exp Ther. 1993 Sep;266(3):1589-93. PubMed PMID: 8396639. 7: Yasoshima K, Yamasaki F, Shinkawa T, Yoshitomi K, Imai M. Effect of a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(IH)-quinolinone-4-oxime-o- sulfonic acid, potassium salt (M17055) on Na+ and K+ transport in the distal nephron segments. J Pharmacol Exp Ther. 1993 Sep;266(3):1581-8. PubMed PMID: 8396638. 8: Shinkawa T, Yamasaki F, Notsu T, Nakakuki M, Nishijima K, Yoshitomi K, Imai M. Loop and distal actions of a novel diuretic, M17055. Eur J Pharmacol. 1993 Jul 20;238(2-3):317-25. PubMed PMID: 8405100. 9: Shinkawa T, Yamasaki F, Kikuchi A, Nakakuki M, Nishijima K, Uemura A, Mizota M, Orita Y. Pharmacological properties of the novel highly potent diuretic 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone 4-oxime-O-sulfonic acid potassium salt. Arzneimittelforschung. 1992 Dec;42(12):1466-72. PubMed PMID: 1337698.