Y08060 is a potent and selective BET Inhibitor for Treatment of Prostate Cancer. Y08060 has IC50 values of 3.23 and 4.41 μM in inhibition of cell viability in the C4−2B and LNCaP cell lines, respectively. Y08060 effectively suppresses cell growth, colony formation, and expression of androgen receptor (AR), AR regulated genes, and MYC in prostate cancer cell lines. In in vivo studies, 36 demonstrates a good PK profile with high oral bioavailability (61.54%) and is a promising lead compound for further prostate cancer drug development.
MedKoo Cat#: 407881
Name: Y08060
CAS#: Unknown
Chemical Formula: C18H19BrN2O6S
Exact Mass: 470.0147
Molecular Weight: 471.32
Elemental Analysis: C, 45.87; H, 4.06; Br, 16.95; N, 5.94; O, 20.37; S, 6.80
The following data is based on the product molecular weight 471.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
