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MedKoo Cat#: 571504 | Name: Aminocaproic acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aminocaproic acid is an Antifibrinolytic Agent used in pediatric heart surgery to decrease surgical bleeding and transfusion. It acts by inhibiting plasminogen activators which have fibrinolytic properties.

Chemical Structure

Aminocaproic acid
Aminocaproic acid
CAS#60-32-2

Theoretical Analysis

MedKoo Cat#: 571504

Name: Aminocaproic acid

CAS#: 60-32-2

Chemical Formula: C6H13NO2

Exact Mass: 131.0946

Molecular Weight: 131.18

Elemental Analysis: C, 54.94; H, 9.99; N, 10.68; O, 24.39

Price and Availability

Size Price Availability Quantity
5g USD 150.00 2 Weeks
25g USD 350.00 2 Weeks
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Related CAS #
No Data
Synonym
Aminocaproic acid; Capracid; Hepin; NSC 26154; NSC-26154; NSC26154
IUPAC/Chemical Name
Hexanoic acid, 6-amino-
InChi Key
SLXKOJJOQWFEFD-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
SMILES Code
O=C(O)CCCCCN
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 131.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Golembiewski J. Antifibrinolytic Use in the Perioperative Setting: Aminocaproic Acid and Tranexamic Acid. J Perianesth Nurs. 2015 Dec;30(6):560-563. doi: 10.1016/j.jopan.2015.09.005. Epub 2015 Oct 21. Review. PubMed PMID: 26596393. 2: Eaton MP, Alfieris GM, Sweeney DM, Angona RE, Cholette JM, Venuto C, Anderson B. Pharmacokinetics of ε-Aminocaproic Acid in Neonates Undergoing Cardiac Surgery with Cardiopulmonary Bypass. Anesthesiology. 2015 May;122(5):1002-9. doi: 10.1097/ALN.0000000000000616. PubMed PMID: 25723765; PubMed Central PMCID: PMC4882606. 3: Fletcher DJ, Brainard BM, Epstein K, Radcliffe R, Divers T. Therapeutic plasma concentrations of epsilon aminocaproic acid and tranexamic acid in horses. J Vet Intern Med. 2013 Nov-Dec;27(6):1589-95. doi: 10.1111/jvim.12202. Epub 2013 Oct 1. PubMed PMID: 24118238. 4: Levine M, Huang M, Henderson SO, Carmelli G, Thomas SH. Aminocaproic Acid and Tranexamic Acid Fail to Reverse Dabigatran-Induced Coagulopathy. Am J Ther. 2016 Nov/Dec;23(6):e1619-e1622. PubMed PMID: 26241703. 5: Anikin IV, Tyndyk ML, Zabezhinskiĭ MA, Popovich IG, Anisimov VN, Pliss GB. [Effect of epsilon-aminocaproic acid, cyclophosphamide and their combination on the growth of autochthonous sarcomas of mice induced by benzo(a)pyrene]. Vopr Onkol. 2014;60(1):94-5. Russian. PubMed PMID: 24772624. 6: Blaine KP, Press C, Lau K, Sliwa J, Rao VK, Hill C. Comparative effectiveness of epsilon-aminocaproic acid and tranexamic acid on postoperative bleeding following cardiac surgery during a national medication shortage. J Clin Anesth. 2016 Dec;35:516-523. doi: 10.1016/j.jclinane.2016.08.037. Epub 2016 Oct 20. PubMed PMID: 27871586. 7: Raghunathan K, Connelly NR, Kanter GJ. ε-Aminocaproic acid and clinical value in cardiac anesthesia. J Cardiothorac Vasc Anesth. 2011 Feb;25(1):16-9. doi: 10.1053/j.jvca.2010.07.024. Epub 2010 Sep 25. PubMed PMID: 20870423. 8: Cuellar JM, Yoo A, Tovar N, Coelho PG, Jimbo R, Vandeweghe S, Kirsch T, Quirno M, Errico TJ. The effects of Amicar and TXA on lumbar spine fusion in an animal model. Spine (Phila Pa 1976). 2014 Sep 1;39(19):E1132-7. doi: 10.1097/BRS.0000000000000488. PubMed PMID: 24979407. 9: Kaye S, Johnson S, Arnold RD, Nie B, Davis JT, Gulland F, Abou-Madi N, Fletcher DJ. PHARMACOKINETIC STUDY OF ORAL ε-AMINOCAPROIC ACID IN THE NORTHERN ELEPHANT SEAL (MIROUNGA ANGUSTIROSTRIS). J Zoo Wildl Med. 2016 Jun;47(2):438-46. doi: 10.1638/2015-0138.1. PubMed PMID: 27468014. 10: Lee U, Choi YH, Kim YG, Lee BK, Oh E, Lee MG. ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation. Xenobiotica. 2012 Mar;42(3):310-5. doi: 10.3109/00498254.2011.619014. Epub 2011 Oct 12. PubMed PMID: 21992030. 11: Han SY, Yang SH, Yoon I, Lee MG, Choi YH. Reduced clearance of ε-acetamidocaproic acid in rats with acute renal failure induced by uranyl nitrate. J Pharm Pharmacol. 2012 Oct;64(10):1452-60. doi: 10.1111/j.2042-7158.2012.01517.x. Epub 2012 Jun 8. PubMed PMID: 22943176. 12: Yoo SH, Venn E, Sullivan LA, Olver CS. Thromboelastographic evidence of inhibition of fibrinolysis after ε-aminocaproic acid administration in a dog with suspected acute traumatic coagulopathy. J Vet Emerg Crit Care (San Antonio). 2016 Sep;26(5):737-42. doi: 10.1111/vec.12467. Epub 2016 Mar 18. PubMed PMID: 26990227. 13: Yurka HG, Wissler RN, Zanghi CN, Liu X, Tu X, Eaton MP; Congenital Heart Surgery Research Interest Group. The effective concentration of epsilon-aminocaproic Acid for inhibition of fibrinolysis in neonatal plasma in vitro. Anesth Analg. 2010 Jul;111(1):180-4. doi: 10.1213/ANE.0b013e3181e19cec. Epub 2010 Jun 2. PubMed PMID: 20519417. 14: Banerjee A, Stoica C, Walia A. Acute hyperkalemia as a complication of intravenous therapy with epsilon-aminocaproic acid. J Clin Anesth. 2011 Nov;23(7):565-8. doi: 10.1016/j.jclinane.2010.12.024. PubMed PMID: 22050802. 15: Munoz JJ, Birkmeyer NJ, Birkmeyer JD, O'Connor GT, Dacey LJ. Is epsilon-aminocaproic acid as effective as aprotinin in reducing bleeding with cardiac surgery?: a meta-analysis. Circulation. 1999 Jan 5-12;99(1):81-9. PubMed PMID: 9884383. 16: Dalmau A, Sabaté A, Acosta F, Garcia-Huete L, Koo M, Sansano T, Rafecas A, Figueras J, Jaurrieta E, Parrilla P. Tranexamic acid reduces red cell transfusion better than epsilon-aminocaproic acid or placebo in liver transplantation. Anesth Analg. 2000 Jul;91(1):29-34. PubMed PMID: 10866882. 17: Singh I, Laungani GB. Intravesical epsilon aminocaproic acid in management of intractable bladder hemorrhage. Urology. 1992 Sep;40(3):227-9. PubMed PMID: 1523745. 18: Kang Y, Lewis JH, Navalgund A, Russell MW, Bontempo FA, Niren LS, Starzl TE. Epsilon-aminocaproic acid for treatment of fibrinolysis during liver transplantation. Anesthesiology. 1987 Jun;66(6):766-73. PubMed PMID: 3296855; PubMed Central PMCID: PMC2965586. 19: Ross J, Dallap BL, Dolente BA, Sweeney RW. Pharmacokinetics and pharmacodynamics of epsilon-aminocaproic acid in horses. Am J Vet Res. 2007 Sep;68(9):1016-21. PubMed PMID: 17764418. 20: Choi YH, Lee U, Suh JH, Kim YG, Lee M, Oh E, Lee MG. Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine. Xenobiotica. 2011 May;41(5):409-15. doi: 10.3109/00498254.2010.549250. Epub 2011 Jan 21. PubMed PMID: 21250786.