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MedKoo Cat#: 562102 | Name: WNK-IN-7

Description:

WARNING: This product is for research use only, not for human or veterinary use.

WNK-IN-7 is a potent and selectiive inhibitor of WNK1 kinase.

Chemical Structure

WNK-IN-7
WNK-IN-7
CAS#2125724-72-1

Theoretical Analysis

MedKoo Cat#: 562102

Name: WNK-IN-7

CAS#: 2125724-72-1

Chemical Formula: C26H29N3O

Exact Mass: 399.2311

Molecular Weight: 399.53

Elemental Analysis: C, 78.16; H, 7.32; N, 10.52; O, 4.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
WNK-IN-7; WNK IN 7; WNKIN7; WNK inhibitor 7; WNK inhibitor-7;
IUPAC/Chemical Name
N-((1-(2-(3-Methoxyphenyl)-5-methylpyridin-4-yl)-1H-indol-3-yl)methyl)-2-methylpropan-1-amine
InChi Key
KRRYUYQXCUJXNA-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H29N3O/c1-18(2)14-27-16-21-17-29(25-11-6-5-10-23(21)25)26-13-24(28-15-19(26)3)20-8-7-9-22(12-20)30-4/h5-13,15,17-18,27H,14,16H2,1-4H3
SMILES Code
CC(C)CNCC1=CN(C2=CC(C3=CC=CC(OC)=C3)=NC=C2C)C4=C1C=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 399.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bhuiyan MIH, Song S, Yuan H, Begum G, Kofler J, Kahle KT, Yang SS, Lin SH, Alper SL, Subramanya AR, Sun D. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. J Cereb Blood Flow Metab. 2017 Aug;37(8):2780-2794. doi: 10.1177/0271678X16675368. Epub 2016 Jan 1. PubMed PMID: 27798271; PubMed Central PMCID: PMC5536788. 2: Wang D, Zhang Y, Han J, Pan S, Xu N, Feng X, Zhuang Z, Caroti C, Zhuang J, Hoover RS, Gu D, Zeng Q, Cai H. WNK3 Kinase Enhances the Sodium Chloride Cotransporter Expression via an ERK 1/2 Signaling Pathway. Nephron. 2016;133(4):287-95. doi: 10.1159/000447717. Epub 2016 Jul 29. PubMed PMID: 27467688. 3: Pasham V, Rotte A, Yang W, Zelenak C, Bhandaru M, Föller M, Lang F. OSR1-sensitive regulation of Na+/H+ exchanger activity in dendritic cells. Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C416-26. doi: 10.1152/ajpcell.00420.2011. Epub 2012 May 30. PubMed PMID: 22648948. 4: Cui Y, Huang Q, Auman JT, Knight B, Jin X, Blanchard KT, Chou J, Jayadev S, Paules RS. Genomic-derived markers for early detection of calcineurin inhibitor immunosuppressant-mediated nephrotoxicity. Toxicol Sci. 2011 Nov;124(1):23-34. doi: 10.1093/toxsci/kfr217. Epub 2011 Aug 24. PubMed PMID: 21865292; PubMed Central PMCID: PMC3196657. 5: Yagi YI, Abe K, Ikebukuro K, Sode K. Kinetic mechanism and inhibitor characterization of WNK1 kinase. Biochemistry. 2009 Nov 3;48(43):10255-66. doi: 10.1021/bi900666n. PubMed PMID: 19739668. 6: Jun P, Hong C, Lal A, Wong JM, McDermott MW, Bollen AW, Plass C, Held WA, Smiraglia DJ, Costello JF. Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific. Neuro Oncol. 2009 Aug;11(4):414-22. doi: 10.1215/15228517-2008-096. Epub 2008 Nov 11. PubMed PMID: 19001526; PubMed Central PMCID: PMC2743221. 7: Cai H, Cebotaru V, Wang YH, Zhang XM, Cebotaru L, Guggino SE, Guggino WB. WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Kidney Int. 2006 Jun;69(12):2162-70. Epub 2006 May 10. PubMed PMID: 16688122. 8: Xu BE, Stippec S, Lenertz L, Lee BH, Zhang W, Lee YK, Cobb MH. WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. J Biol Chem. 2004 Feb 27;279(9):7826-31. Epub 2003 Dec 16. PubMed PMID: 14681216.