MedKoo Cat#: 562096 | Name: RIPK2-IN-8

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RIPK2-IN-8 is a potent and selective RIPK2 inhibitor.

Chemical Structure

RIPK2-IN-8
RIPK2-IN-8
CAS#2141969-56-2

Theoretical Analysis

MedKoo Cat#: 562096

Name: RIPK2-IN-8

CAS#: 2141969-56-2

Chemical Formula: C18H21FN4O3S

Exact Mass: 392.1318

Molecular Weight: 392.44

Elemental Analysis: C, 55.09; H, 5.39; F, 4.84; N, 14.28; O, 12.23; S, 8.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
RIPK2-IN-8; RIPK2 IN 8; RIPK2IN8; RIPK2 inhibitor 8; RIPK2 inhibitor-8;
IUPAC/Chemical Name
4-(6-(tert-Butylsulfonyl)-7-ethoxyimidazo[1,2-a]pyridin-3-yl)-6-fluoropyridin-2-amine
InChi Key
QWDMZDSZMVJFFJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21FN4O3S/c1-5-26-13-8-17-21-9-12(11-6-15(19)22-16(20)7-11)23(17)10-14(13)27(24,25)18(2,3)4/h6-10H,5H2,1-4H3,(H2,20,22)
SMILES Code
NC1=NC(F)=CC(C2=CN=C3C=C(OCC)C(S(=O)(C(C)(C)C)=O)=CN32)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 392.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: He X, Da Ros S, Nelson J, Zhu X, Jiang T, Okram B, Jiang S, Michellys PY, Iskandar M, Espinola S, Jia Y, Bursulaya B, Kreusch A, Gao MY, Spraggon G, Baaten J, Clemmer L, Meeusen S, Huang D, Hill R, Nguyen-Tran V, Fathman J, Liu B, Tuntland T, Gordon P, Hollenbeck T, Ng K, Shi J, Bordone L, Liu H. Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases. ACS Med Chem Lett. 2017 Sep 27;8(10):1048-1053. doi: 10.1021/acsmedchemlett.7b00258. eCollection 2017 Oct 12. PubMed PMID: 29057049; PubMed Central PMCID: PMC5641954. 2: Han NR, Moon PD, Jeong HJ, Kim HM. Hydrogen sulfide diminishes the levels of thymic stromal lymphopoietin in activated mast cells. Arch Dermatol Res. 2016 Mar;308(2):103-13. doi: 10.1007/s00403-016-1619-x. Epub 2016 Jan 20. PubMed PMID: 26791024. 3: Wu J, Zhang Y, Xin Z, Wu X. The crosstalk between TLR2 and NOD2 in Aspergillus fumigatus keratitis. Mol Immunol. 2015 Apr;64(2):235-43. doi: 10.1016/j.molimm.2014.11.021. Epub 2014 Dec 27. PubMed PMID: 25549945. 4: Damgaard RB, Fiil BK, Speckmann C, Yabal M, zur Stadt U, Bekker-Jensen S, Jost PJ, Ehl S, Mailand N, Gyrd-Hansen M. Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling. EMBO Mol Med. 2013 Aug;5(8):1278-95. doi: 10.1002/emmm.201303090. Epub 2013 Jul 1. PubMed PMID: 23818254; PubMed Central PMCID: PMC3944466. 5: Madrigal AG, Barth K, Papadopoulos G, Genco CA. Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells. PLoS Pathog. 2012;8(6):e1002723. doi: 10.1371/journal.ppat.1002723. Epub 2012 Jun 7. PubMed PMID: 22685397; PubMed Central PMCID: PMC3369954. 6: Moreno L, McMaster SK, Gatheral T, Bailey LK, Harrington LS, Cartwright N, Armstrong PC, Warner TD, Paul-Clark M, Mitchell JA. Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages. Br J Pharmacol. 2010 Aug;160(8):1997-2007. doi: 10.1111/j.1476-5381.2010.00814.x. PubMed PMID: 20649597; PubMed Central PMCID: PMC2913099. 7: Krieg A, Correa RG, Garrison JB, Le Negrate G, Welsh K, Huang Z, Knoefel WT, Reed JC. XIAP mediates NOD signaling via interaction with RIP2. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14524-9. doi: 10.1073/pnas.0907131106. Epub 2009 Aug 10. PubMed PMID: 19667203; PubMed Central PMCID: PMC2732880. 8: Usluoglu N, Pavlovic J, Moelling K, Radziwill G. RIP2 mediates LPS-induced p38 and IkappaBalpha signaling including IL-12 p40 expression in human monocyte-derived dendritic cells. Eur J Immunol. 2007 Aug;37(8):2317-25. PubMed PMID: 17578844. 9: Quintavalle M, Sambucini S, Summa V, Orsatti L, Talamo F, De Francesco R, Neddermann P. Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors. J Biol Chem. 2007 Feb 23;282(8):5536-44. Epub 2006 Dec 13. PubMed PMID: 17166835. 10: Wang X, Narayanan M, Bruey JM, Rigamonti D, Cattaneo E, Reed JC, Friedlander RM. Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. Biochim Biophys Acta. 2006 Aug;1762(8):742-54. Epub 2006 Jul 21. PubMed PMID: 16920334. 11: Rosenstiel P, Huse K, Till A, Hampe J, Hellmig S, Sina C, Billmann S, von Kampen O, Waetzig GH, Platzer M, Seegert D, Schreiber S. A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3280-5. Epub 2006 Feb 21. PubMed PMID: 16492792; PubMed Central PMCID: PMC1413865. 12: Inohara N, del Peso L, Koseki T, Chen S, Núñez G. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J Biol Chem. 1998 May 15;273(20):12296-300. Erratum in: J Biol Chem 1998 Jul 17;273(29):18675. PubMed PMID: 9575181.