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MedKoo Cat#: 341046 | Name: Prolylleucine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prolylleucine is a biochemical.

Chemical Structure

Prolylleucine
Prolylleucine
CAS#61596-47-2

Theoretical Analysis

MedKoo Cat#: 341046

Name: Prolylleucine

CAS#: 61596-47-2

Chemical Formula: C19H26N2O5

Exact Mass: 362.1842

Molecular Weight: 362.43

Elemental Analysis: C, 62.97; H, 7.23; N, 7.73; O, 22.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Prolylleucine
IUPAC/Chemical Name
D-Leucine, N-(1-((phenylmethoxy)carbonyl)-L-prolyl)-
InChi Key
YCYXUKRYYSXSLJ-CVEARBPZSA-N
InChi Code
InChI=1S/C19H26N2O5/c1-13(2)11-15(18(23)24)20-17(22)16-9-6-10-21(16)19(25)26-12-14-7-4-3-5-8-14/h3-5,7-8,13,15-16H,6,9-12H2,1-2H3,(H,20,22)(H,23,24)/t15-,16+/m1/s1
SMILES Code
C([C@H](NC([C@H]1N(CCC1)C(=O)OCc1ccccc1)=O)CC(C)C)(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 362.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 12636389. 7: Guédon E, Renault P, Ehrlich SD, Delorme C. Transcriptional pattern of genes coding for the proteolytic system of Lactococcus lactis and evidence for coordinated regulation of key enzymes by peptide supply. J Bacteriol. 2001 Jun;183(12):3614-22. PubMed PMID: 11371525; PubMed Central PMCID: PMC95238. 8: Meijer W, Marugg JD, Hugenholtz J. Regulation of Proteolytic Enzyme Activity in Lactococcus lactis. Appl Environ Microbiol. 1996 Jan;62(1):156-61. PubMed PMID: 16535207; PubMed Central PMCID: PMC1388749. 9: Marugg JD, Meijer W, van Kranenburg R, Laverman P, Bruinenberg PG, de Vos WM. Medium-dependent regulation of proteinase gene expression in Lactococcus lactis: control of transcription initiation by specific dipeptides. J Bacteriol. 1995 Jun;177(11):2982-9. PubMed PMID: 7768792; PubMed Central PMCID: PMC176983. 10: Kulikov NV, Basok SS, Lukyanenko NG. Studies on the carbodiimide-mediated model couplings of Z-Pro-Leu-OH with benzoaza-15-crown-5. Int J Pept Protein Res. 1993 Jul;42(1):20-3. PubMed PMID: 8370639. 11: Codini M, Palmerini CA, Fini C, Lucarelli C, Floridi A. High-performance liquid chromatographic method for the determination of prolyl peptides in urine. J Chromatogr. 1991 Jan 4;536(1-2):337-41. PubMed PMID: 2050773. 12: de Roux N, Chadeuf G, Molho-Sabatier P, Plouin PF, Aiach M. Clinical and biochemical characterization of antithrombin III Franconville, a variant with Pro 41 Leu mutation. Br J Haematol. 1990 Jun;75(2):222-7. PubMed PMID: 2372510. 13: Panneerselvam K, Chacko KK. Structure and conformation of peptides involving prolyl residue. IV. L-Prolyl-L-leucine monohydrate. Int J Pept Protein Res. 1990 May;35(5):460-4. PubMed PMID: 2376471. 14: Kovács GL, Sarnyai Z, Izbéki F, Szabó G, Telegdy G, Barth T, Jost K, Brtnik F. Effects of oxytocin-related peptides on acute morphine tolerance: opposite actions by oxytocin and its receptor antagonists. J Pharmacol Exp Ther. 1987 May;241(2):569-74. PubMed PMID: 3033220. 15: Szabó G, Kovács GL, Székeli S, Baláspiri L, Telegdy G. C-terminal fragments of oxytocin (prolyl-leucyl-glycinamide and Z-prolyl-D-leucine) attenuate the development of tolerance to ethanol. Acta Physiol Hung. 1987;69(1):115-22. PubMed PMID: 2884803. 16: Kovács GL, Horváth Z, Sarnyai Z, Faludi M, Telegdy G. Oxytocin and a C-terminal derivative (Z-prolyl-D-leucine) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain. Neuropharmacology. 1985 May;24(5):413-9. PubMed PMID: 2991800. 17: Kovács GL, Izbéki F, Horváth Z, Telegdy G. Effects of oxytocin and a derivative (Z-prolyl-D-leucine) on morphine tolerance/withdrawal are mediated by the limbic system. Behav Brain Res. 1984 Oct;14(1):1-8. PubMed PMID: 6542796. 18: Kovács GL, Telegdy G, Hódi K. Drugs affecting brain dopamine interfere with the effect of Z-prolyl-D-leucine on morphine withdrawal. Pharmacol Biochem Behav. 1984 Sep;21(3):345-8. PubMed PMID: 6541792. 19: Chipkin RE, Latranyi MB. Effect of cyclo-leucyl-glycine in the rat yeast-paw test. Eur J Pharmacol. 1984 Apr 20;100(2):239-41. PubMed PMID: 6539706. 20: Kovács GL, Szontágh L, Baláspiri L, Telegdy G. Dipeptides delay the onset of morphine withdrawal in the mouse. Acta Physiol Hung. 1984;63(1):83-4. PubMed PMID: 6540034.

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Prolinal

Prolinal