MedKoo Cat#: 584322 | Name: Amoscanate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amoscanate is an antiparasitic agent that is highly effective in animals against the four major species of schistosomes which infect humans.

Chemical Structure

Amoscanate
Amoscanate
CAS#26328-53-0

Theoretical Analysis

MedKoo Cat#: 584322

Name: Amoscanate

CAS#: 26328-53-0

Chemical Formula: C13H9N3O2S

Exact Mass: 271.0415

Molecular Weight: 271.29

Elemental Analysis: C, 57.55; H, 3.34; N, 15.49; O, 11.79; S, 11.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Amoscanate; C 9333 GO; CCRIS 4111; CGP 4540; Ciba 9333 GO; GO 9333
IUPAC/Chemical Name
Benzenamine, 4-isothiocyanato-N-(4-nitrophenyl)- (9CI)
InChi Key
DKVNAGXPRSYHLB-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H9N3O2S/c17-16(18)13-7-5-12(6-8-13)15-11-3-1-10(2-4-11)14-9-19/h1-8,15H
SMILES Code
O=[N+](C1=CC=C(NC2=CC=C(N=C=S)C=C2)C=C1)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 271.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Leitch B, Probert AJ. Schistosoma haematobium: amoscanate and adult worm ultrastructure. Exp Parasitol. 1984 Dec;58(3):278-89. PubMed PMID: 6500001. 2: Nelson NF, Saz HJ. Hymenolepis diminuta: effects of amoscanate on energy metabolism and ultrastructure. Exp Parasitol. 1983 Aug;56(1):55-69. PubMed PMID: 6409659. 3: Walter RD, Albiez EJ. Interaction of amoscanate with the cyclic AMP-phosphodiesterases from Schistosoma mansoni, Onchocerca volvulus and bovine heart. Tropenmed Parasitol. 1984 Jun;35(2):78-80. PubMed PMID: 6087521. 4: Voge M, Bueding E. Schistosoma mansoni: tegumental surface alterations induced by subcurative doses of the schistosomicide amoscanate. Exp Parasitol. 1980 Oct;50(2):251-9. PubMed PMID: 7409075. 5: Batzinger RP, Bueding E, Popper H. Protection by antibiotics against experimental focal cholangitis produced in mice by a schistosomicidal isothiocyanate. Hepatology. 1981 Jan-Feb;1(1):21-7. PubMed PMID: 7286888. 6: Barton BE, Levy DA. The immune response to a schistosomacide, amoscanate. I. Serum antibody responses. J Immunopharmacol. 1985;7(3):343-71. PubMed PMID: 2414366. 7: Greene LK, Grenan MM, Davidson DE Jr, Jones DH, Shedd TR. Amoscanate as a topically applied chemical for prophylaxis against Schistosoma mansoni infections in mice. Am J Trop Med Hyg. 1983 Nov;32(6):1356-63. PubMed PMID: 6650736. 8: Reddy AB, Rao UR, Chandrashekar R, Shrivastava R, Subrahmanyam D. Comparative efficacy of some benzimidazoles and amoscanate (Go.9333) against experimental filarial infections. Tropenmed Parasitol. 1983 Dec;34(4):259-62. PubMed PMID: 6665868. 9: Barton BE, Levy DA. The immune response to a schistosomacide, amoscanate. II. Cell-mediated immune responses. J Immunopharmacol. 1985;7(3):373-83. PubMed PMID: 4056413. 10: Khalil SB, Girgis NI, Mansour NS. Studies on the effect of Amoscanate on the immature stages of S. mansoni and S. haematobium worms in hamsters. J Egypt Soc Parasitol. 1986 Dec;16(2):699-706. PubMed PMID: 3097173. 11: Knasmüller S, Kerklaan P, Mohn GR. Use of the DNA-repair host-mediated assay for determining the organ distribution of genotoxic factors in mice treated orally with nitro-aromatic compounds. Mutat Res. 1986 Feb;164(1):9-17. PubMed PMID: 2419751. 12: Franz M, Zahner H, Mehlhorn H, Striebel HP. In vivo effect of benzothiazole and amoscanate derivatives on the fine structure of adult Brugia spp. and Litomosoides carinii. Parasitol Res. 1990;76(5):393-400. PubMed PMID: 2352916. 13: Sabah AA, Fletcher C, Webbe G, Doenhoff MJ. Schistosoma mansoni: chemotherapy of infections of different ages. Exp Parasitol. 1986 Jun;61(3):294-303. PubMed PMID: 3086114. 14: Shapiro TA, Were JB, Talalay P, Bueding E, Rocco L, Danso K, Massof R, Green R, Mellits ED, Lietman PS. Clinical evaluation of amoscanate in healthy male volunteers. Am J Trop Med Hyg. 1986 Sep;35(5):945-53. PubMed PMID: 3766854. 15: Johanson C, Stopa E, McMillan P, Roth D, Funk J, Krinke G. The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol. 2011 Jan;39(1):186-212. doi: 10.1177/0192623310394214. Epub 2010 Dec 28. Review. PubMed PMID: 21189316. 16: Davies KP, Zahner H, Köhler P. Litomosoides carinii: mode of action in vitro of benzothiazole and amoscanate derivatives with antifilarial activity. Exp Parasitol. 1989 May;68(4):382-91. PubMed PMID: 2721632. 17: Krinke G, Graepel P, Krueger L, Thomann P. Early effects of high-dosed absorbable amoscanate on rat brain. Toxicol Lett. 1983 Dec;19(3):261-6. PubMed PMID: 6658839. 18: Miao HZ. [Amoscanate induced liver injury. I. Clinical observation (author's transl)]. Zhonghua Nei Ke Za Zhi. 1981 Jul;20(7):430-2. Chinese. PubMed PMID: 7327065. 19: Cheever AW, Deb S. Persistence of hepatic fibrosis and tissue eggs following treatment of Schistosoma japonicum infected mice. Am J Trop Med Hyg. 1989 Jun;40(6):620-8. PubMed PMID: 2500856. 20: Walter RD, Albiez E. Parasite-specific inhibition of 5'-nucleotidase from Onchocerca volvulus and Dirofilaria immitis by the amoscanate-derivative CGP 8065. Mol Biochem Parasitol. 1985 Aug;16(2):109-15. PubMed PMID: 2993882.