Thiambutosine | CAS#500-89-0 | Leprosy treatment candidate

MedKoo Cat#: 329997 | Name: Thiambutosine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thiambutosine was a candidate for treatment of lepromatous leprosy.

Chemical Structure

Thiambutosine

CAS#500-89-0

Theoretical Analysis

MedKoo Cat#: 329997

Name: Thiambutosine

CAS#: 500-89-0

Chemical Formula: C19H25N3OS

Exact Mass: 343.1718

Molecular Weight: 343.49

Elemental Analysis: C, 66.44; H, 7.34; N, 12.23; O, 4.66; S, 9.33

Price and Availability

Size	Price	Availability
100mg	USD 650.00	2 Weeks
200mg	USD 950.00	2 Weeks
500mg	USD 1,450.00	2 Weeks
1g	USD 1,950.00	2 Weeks
2g	USD 2,950.00	2 Weeks
5g	USD 4,950.00	2 Weeks

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Related CAS #

No Data

Synonym

Thiambutosine; SC 682; SC682; SC-682; SU-1906; SU1906; SU 1906; Summit 1906; Ciba 1906;

IUPAC/Chemical Name

1-(p-Butoxyphenyl)-3-(p-dimethylaminophenyl)-2-thiourea

InChi Key

JYCBKPOKWDDOOV-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H25N3OS/c1-4-5-14-23-18-12-8-16(9-13-18)21-19(24)20-15-6-10-17(11-7-15)22(2)3/h6-13H,4-5,14H2,1-3H3,(H2,20,21,24)

SMILES Code

S=C(NC1=CC=C(N(C)C)C=C1)NC2=CC=C(OCCCC)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 343.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Smith TC, Richardus JH. Relapse rates in patients treated with dapsone monotherapy and combinations of dapsone and thiambutosine, thiacetazone, isoniazid and streptomycin in the pre-MDT era. Int J Lepr Other Mycobact Dis. 1994 Sep;62(3):353-8. PMID: 7525795. 2: Evans AT, Croft SL, Peters W, Neal RA. Antileishmanial effects of clofazimine and other antimycobacterial agents. Ann Trop Med Parasitol. 1989 Oct;83(5):447-54. doi: 10.1080/00034983.1989.11812371. PMID: 2619361. 3: Khan HM. Clinical therapeutic analysis of vitiligo phase--II. Bangladesh Med Res Counc Bull. 1984 Dec;10(2):71-5. PMID: 6543425. 4: Mikhailov P, Dimitrova I. Die lepra in Bulgarien. Epidemologie, Klinische Formen und Therapie [Leprosy in Bulgaria. Epidemiology, Clinical forms and treatment (author's transl)]. Z Hautkr. 1981 Oct 15;56(20):1364-70. German. PMID: 7197852. 5: Anand LC, Tiwari VD, Rathore BS, Singh O. Clinical trial with CIBA 1906 in lepromatous leprosy. Lepr India. 1981 Apr;53(2):278-84. PMID: 7019567. 6: Pattyn SR, Colston MJ. Cross-resistance amongst thiambutosine, thiacetazone, ethionamide and prothionamide with Mycobacterium leprae. Lepr Rev. 1978 Dec;49(4):324-6. PMID: 84317. 7: Colston MJ, Hilson GR, Ellard GA, Gammon PT. The activity of thiacetazone, thiambutosine, thiocarlide and sulphamethoxypyridazine against Mycobacterium leprae in mice. Lepr Rev. 1978 Jun;49(2):101-13. PMID: 78428. 8: Waters MF, Rees RJ, Pearson JM, Laing AB, Helmy HS, Gelber RH. Rifampicin for lepromatous leprosy: nine years' experience. Br Med J. 1978 Jan 21;1(6106):133-6. doi: 10.1136/bmj.1.6106.133. PMID: 339995; PMCID: PMC1602838. 9: Waters MF, Pearson JM, Rees RJ. Drug resistant leprosy--a comparison between proven dapsone and proven thiambutosine resistance. Int J Lepr Other Mycobact Dis. 1976 Jan-Jun;44(1-2):152-3. PMID: 776850. 10: Colston MJ, Hilson GR. The activity of thiacetazone, thiambutosine and thiocarlide in the chemotherapy of experimental leprosy. Int J Lepr Other Mycobact Dis. 1976 Jan-Jun;44(1-2):123. PMID: 58847. 11: Levy L, Ullmann NM. Inhibition of multiplication of Mycobacterium leprae by several antithyroid drugs. Am Rev Respir Dis. 1975 May;111(5):651-5. doi: 10.1164/arrd.1975.111.5.651. PMID: 48349. 12: Devani MB, Shishoo CJ, Mody HJ. Spectrophotometric determination of thiambutosine. Analyst. 1975 Mar;100(1188):178-81. doi: 10.1039/an9750000178. PMID: 1137192. 13: Convit J, Browne SG, Languillon J, Pettit JH, Ramanujam K, Sagher F, Sheskin J, Tarabini G, de Souza Lima L, Tolentino JG, Waters MF, Bechelli LM, Martínez Domínguez V. Therapy of leprosy. Bull World Health Organ. 1970;42(5):667-72. PMID: 5311056; PMCID: PMC2427498. 14: Garrod JM, Ellard GA. Appearance of resistance during prolonged treatment of leprosy with Thiambutosine. Lepr Rev. 1968 Jul;39(3):113-7. doi: 10.5935/0305-7518.19680021. PMID: 5663677. 15: Schulz EJ, Egnal ML, Doevendans G. Treatment of leprosy with a combination of injectable thiambutosine (CIBA 1906), streptomycin and isoniazid. Lepr Rev. 1966 Jan;37(1):47-8. doi: 10.5935/0305-7518.19660011. PMID: 5908575. 16: Ellard GA. A preliminary study of the absorption, metabolism and excretion of injectable thiambutosine. Lepr Rev. 1966 Jan;37(1):17-22. doi: 10.5935/0305-7518.19660003. PMID: 5908570. 17: BROWNE SG. A LIMITED CLINICAL TRIAL OF INJECTABLE THIAMBUTOSINE. Lepr Rev. 1965 Jan;36:21-2. doi: 10.5935/0305-7518.19650006. PMID: 14241914. 18: Kradolfer F, Bloch H. Intermittent combination therapy with INH and thiambutosine (CIBA-1906) in tuberculous mice. Pathol Microbiol (Basel). 1965;28(4):717-27. doi: 10.1159/000161826. PMID: 5836688. 19: DARRAS T. ESSAI DE TRAITEMENT AMBULATOIRE DE LA TUBERCULOSE PULMONAIRE PAR L'ASSOCIATION 1906 CIBA (DPT)-INH [STUDY OF AMBULATORY TREATMENT OF PULMONARY TUBERCULOSIS WITH THE COMBINATION OF 1906 CIBA (DPT) AND INH]. Ann Soc Belges Med Trop Parasitol Mycol. 1964;44:415-21. French. PMID: 14259245. 20: GONZALEZ-OCHOA A, DOMINGUEZ SOTO L. [Preliminary report on clinical experimentation in leprosy using 1-(4-butoxyphenyl)-3-(4-dimethylaminophenyl)-2-thiourea (compound Ciba 1906)]. Rev Inst Salubr Enferm Trop. 1962 Jun;22:51-6. Spanish. PMID: 13949040.