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MedKoo Cat#: 562048 | Name: PARPi-FL

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PARPi-FL is a fluorescent PARP imaging agent. It is capable of detecting target engagement of a PARP inhibitor panel in vitro.

Chemical Structure

PARPi-FL
PARPi-FL
CAS#1380359-84-1

Theoretical Analysis

MedKoo Cat#: 562048

Name: PARPi-FL

CAS#: 1380359-84-1

Chemical Formula: C34H32BF3N6O3

Exact Mass: 640.2581

Molecular Weight: 640.47

Elemental Analysis: C, 63.76; H, 5.04; B, 1.69; F, 8.90; N, 13.12; O, 7.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PARPi-FL; PARPi FL; PARPiFL; Olaparib-bodipy FL; Olaparib bodipy FL;
IUPAC/Chemical Name
5,5-Difluoro-7-(3-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-3-oxopropyl)-1,3-dimethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide
InChi Key
IGUTVNUEFKPBGK-UHFFFAOYSA-N
InChi Code
InChI=1S/C34H32BF3N6O3/c1-21-17-22(2)43-31(21)20-25-9-8-24(44(25)35(43,37)38)10-12-32(45)41-13-15-42(16-14-41)34(47)28-18-23(7-11-29(28)36)19-30-26-5-3-4-6-27(26)33(46)40-39-30/h3-9,11,17-18,20H,10,12-16,19H2,1-2H3,(H,40,46)
SMILES Code
CC1=[N+](C(C(C)=C1)=C2)[B-](F)(F)N3C2=CC=C3CCC(N4CCN(C(C5=CC(CC6=NNC(C7=C6C=CC=C7)=O)=CC=C5F)=O)CC4)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 640.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang J. Poly (ADP-ribose) polymerase inhibitor: an evolving paradigm in the treatment of prostate cancer. Asian J Androl. 2014 May-Jun;16(3):401-6. doi: 10.4103/1008-682X.123684. Review. PubMed PMID: 24589464; PubMed Central PMCID: PMC4023365. 2: Shackelford RE, Mayhall K, Maxwell NM, Kandil E, Coppola D. Nicotinamide phosphoribosyltransferase in malignancy: a review. Genes Cancer. 2013 Nov;4(11-12):447-56. doi: 10.1177/1947601913507576. Review. PubMed PMID: 24386506; PubMed Central PMCID: PMC3877665. 3: Mason KA, Raju U, Buchholz TA, Wang L, Milas ZL, Milas L. Poly (ADP-ribose) polymerase inhibitors in cancer treatment. Am J Clin Oncol. 2014 Feb;37(1):90-100. doi: 10.1097/COC.0b013e3182467dce. Review. PubMed PMID: 22495455. 4: Ismail-Khan R, Bui MM. A review of triple-negative breast cancer. Cancer Control. 2010 Jul;17(3):173-6. Review. PubMed PMID: 20664514. 5: Price M, Monteiro AN. Fine tuning chemotherapy to match BRCA1 status. Biochem Pharmacol. 2010 Sep 1;80(5):647-53. doi: 10.1016/j.bcp.2010.05.015. Epub 2010 May 25. Review. PubMed PMID: 20510205; PubMed Central PMCID: PMC2925507.