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MedKoo Cat#: 562047 | Name: (-)-S-Timolol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(-)-S-Timolol is a beta-Adrenergic antagonist.

Chemical Structure

(-)-S-Timolol
(-)-S-Timolol
CAS#91524-16-2

Theoretical Analysis

MedKoo Cat#: 562047

Name: (-)-S-Timolol

CAS#: 91524-16-2

Chemical Formula: C13H24N4O3S

Exact Mass: 316.1569

Molecular Weight: 316.42

Elemental Analysis: C, 49.35; H, 7.65; N, 17.71; O, 15.17; S, 10.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
(-)-S-Timolol; (-) S Timolol;
IUPAC/Chemical Name
(2S)-1-(tert-Butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol
InChi Key
BLJRIMJGRPQVNF-JTQLQIEISA-N
InChi Code
InChI=1S/C13H24N4O3S/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,1-3H3/t10-/m0/s1
SMILES Code
O[C@H](COC1=NSN=C1N2CCOCC2)CNC(C)(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 316.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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A model-based dose-response meta-analysis of ocular hypotensive agents as a drug development tool to evaluate new therapies in glaucoma. J Ocul Pharmacol Ther. 2015 May;31(4):189-97. doi: 10.1089/jop.2014.0106. Epub 2015 Feb 25. Review. PubMed PMID: 25714918. 8: Borowicz KK, Banach M. Antiarrhythmic drugs and epilepsy. Pharmacol Rep. 2014 Aug;66(4):545-51. doi: 10.1016/j.pharep.2014.03.009. Epub 2014 Apr 13. Review. PubMed PMID: 24948053. 9: Lou H, Zong Y, Ge YR, Cheng JW, Wei RL. Efficacy and tolerability of latanoprost compared with timolol in the treatment of patients with chronic angle-closure glaucoma. Curr Med Res Opin. 2014 Jul;30(7):1367-73. doi: 10.1185/03007995.2014.905825. Epub 2014 Mar 27. Review. PubMed PMID: 24641069. 10: Ganekal S, Dorairaj S, Jhanji V, Kudlu K. Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma. J Curr Glaucoma Pract. 2014 Jan-Apr;8(1):15-9. doi: 10.5005/jp-journals-10008-1155. Epub 2014 Jan 16. Review. PubMed PMID: 26997802; PubMed Central PMCID: PMC4741158. 11: Lubahn JG, Lee RK, Karp CL. Resolution of conjunctival sessile hemangioma with topical timolol. Cornea. 2014 Jan;33(1):99-100. doi: 10.1097/ICO.0000000000000022. Review. PubMed PMID: 24270678; PubMed Central PMCID: PMC3895456. 12: Magee L, von Dadelszen P. Prevention and treatment of postpartum hypertension. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD004351. doi: 10.1002/14651858.CD004351.pub3. Review. PubMed PMID: 23633317. 13: Cheng JW, Cheng SW, Gao LD, Lu GC, Wei RL. Intraocular pressure-lowering effects of commonly used fixed-combination drugs with timolol: a systematic review and meta-analysis. PLoS One. 2012;7(9):e45079. doi: 10.1371/journal.pone.0045079. Epub 2012 Sep 13. Review. PubMed PMID: 23028770; PubMed Central PMCID: PMC3441590. 14: Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E; Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2012 Apr 24;78(17):1337-45. doi: 10.1212/WNL.0b013e3182535d20. Review. Erratum in: Neurology. 2013 Feb 26;80(9):871. PubMed PMID: 22529202; PubMed Central PMCID: PMC3335452. 15: Aptel F, Denis P. Balancing efficacy and tolerability of prostaglandin analogues and prostaglandin-timolol fixed combinations in primary open-angle glaucoma. Curr Med Res Opin. 2011 Oct;27(10):1949-58. doi: 10.1185/03007995.2011.613923. Epub 2011 Aug 31. Review. PubMed PMID: 21878000. 16: Ni N, Guo S, Langer P. Current concepts in the management of periocular infantile (capillary) hemangioma. Curr Opin Ophthalmol. 2011 Sep;22(5):419-25. doi: 10.1097/ICU.0b013e32834994b4. Review. PubMed PMID: 21730838. 17: Arthur S, Cantor LB. Update on the role of alpha-agonists in glaucoma management. Exp Eye Res. 2011 Sep;93(3):271-83. doi: 10.1016/j.exer.2011.04.002. Epub 2011 Apr 20. Review. PubMed PMID: 21524649. 18: Tressler CS, Wiseman RL, Dombi TM, Jessen B, Huang K, Kwok KK, Wirostko BM. Lack of evidence for a link between latanoprost use and malignant melanoma: an analysis of safety databases and a review of the literature. Br J Ophthalmol. 2011 Nov;95(11):1490-5. doi: 10.1136/bjo.2010.193987. Epub 2011 Apr 21. Review. PubMed PMID: 21515566. 19: Denis P. Travoprost/timolol fixed combination in the management of open-angle glaucoma: a clinical review. Expert Opin Pharmacother. 2011 Feb;12(3):463-71. doi: 10.1517/14656566.2011.551007. Review. PubMed PMID: 21254951. 20: Gray RN, Goslin RE, McCrory DC, Eberlein K, Tulsky J, Hasselblad V. Drug Treatments for the Prevention of Migraine Headache. Rockville (MD): Agency for Health Care Policy and Research (US); 1999 Feb. PubMed PMID: 20945567.