MedKoo Cat#: 620119 | Name: Mc-Val-Ala-PAB
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mc-Val-Ala-PAB is a useful linker to make antibody-drug-conjugate (ADC) for targeting drug delivery.

Chemical Structure

Mc-Val-Ala-PAB
Mc-Val-Ala-PAB
CAS#1870916-87-2

Theoretical Analysis

MedKoo Cat#: 620119

Name: Mc-Val-Ala-PAB

CAS#: 1870916-87-2

Chemical Formula: C25H34N4O6

Exact Mass: 486.2478

Molecular Weight: 486.57

Elemental Analysis: C, 61.71; H, 7.04; N, 11.51; O, 19.73

Price and Availability

Size Price Availability Quantity
1g USD 1,850.00 2 Weeks
2g USD 3,050.00 2 Weeks
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Related CAS #
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Synonym
Mc-Val-Ala-PAB, Mc-Val-Ala-PAB-OH; ACD linker.
IUPAC/Chemical Name
6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide
InChi Key
DAMSURYLURICHN-SBUREZEXSA-N
InChi Code
InChI=1S/C25H34N4O6/c1-16(2)23(28-20(31)7-5-4-6-14-29-21(32)12-13-22(29)33)25(35)26-17(3)24(34)27-19-10-8-18(15-30)9-11-19/h8-13,16-17,23,30H,4-7,14-15H2,1-3H3,(H,26,35)(H,27,34)(H,28,31)/t17-,23-/m0/s1
SMILES Code
O=C(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C1)=CC=C1CO)=O)=O)CCCCCN2C(C=CC2=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Mc-Val-Ala-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 486.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
Beck A, Goetsch L, Dumontet C, Corvaïa N. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. doi: 10.1038/nrd.2016.268. Epub 2017 Mar 17. PMID: 28303026.