Synonym
BRP-7; BRP 7; BRP7;
IUPAC/Chemical Name
2-(1-(4-(Benzyloxy)phenyl)ethyl)-1-(2-chlorobenzyl)-1H-benzo[d]imidazole
InChi Key
WVJPAJJFVVPBER-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H25ClN2O/c1-21(23-15-17-25(18-16-23)33-20-22-9-3-2-4-10-22)29-31-27-13-7-8-14-28(27)32(29)19-24-11-5-6-12-26(24)30/h2-18,21H,19-20H2,1H3
SMILES Code
ClC1=CC=CC=C1CN2C(C(C3=CC=C(OCC4=CC=CC=C4)C=C3)C)=NC5=CC=CC=C25
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
452.98
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Levent S, Gerstmeier J, Olgaç A, Nikels F, Garscha U, Carotti A, Macchiarulo A, Werz O, Banoglu E, Çalışkan B. Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7. Eur J Med Chem. 2016 Oct 21;122:510-519. doi: 10.1016/j.ejmech.2016.07.004. Epub 2016 Jul 5. PubMed PMID: 27423639.
2: Pergola C, Gerstmeier J, Mönch B, Çalışkan B, Luderer S, Weinigel C, Barz D, Maczewsky J, Pace S, Rossi A, Sautebin L, Banoglu E, Werz O. The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP). Br J Pharmacol. 2014 Jun;171(12):3051-64. doi: 10.1111/bph.12625. PubMed PMID: 24641614; PubMed Central PMCID: PMC4055205.
