MedKoo Cat#: 562020 | Name: AG-183
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase.

Chemical Structure

AG-183
CAS#122520-90-5

Theoretical Analysis

MedKoo Cat#: 562020

Name: AG-183

CAS#: 122520-90-5

Chemical Formula: C13H8N4O3

Exact Mass: 268.0596

Molecular Weight: 268.23

Elemental Analysis: C, 58.21; H, 3.01; N, 20.89; O, 17.89

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
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Related CAS #
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Synonym
AG-183; AG 183; AG183; Tyrphostin 51; Tyrphostin-51; Tyrphostin51;
IUPAC/Chemical Name
3-Amino-2,4-dicyano-5-(3',4',5'-trihydroxyphenyl)penta-2,4-dienonitrile
InChi Key
JKNOYWVMHPMBEL-UNXLUWIOSA-N
InChi Code
InChI=1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,18-20H,17H2/b8-1+
SMILES Code
N#C/C(C#N)=C(N)/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 268.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: First MB, Frances A. Issues for DSM-V: unintended consequences of small changes: the case of paraphilias. Am J Psychiatry. 2008 Oct;165(10):1240-1. doi: 10.1176/appi.ajp.2008.08030361. Erratum in: Am J Psychiatry. 2008 Nov;165(11):1495. PMID: 18829878. 2: Lander HM, Levine DM, Novogrodsky A. Agonistic effects of tyrphostins on human peripheral mononuclear cells. Cell Immunol. 1992 Oct 1;144(1):155-68. doi: 10.1016/0008-8749(92)90233-f. PMID: 1394436. 3: Melamed I, Downey GP, Roifman CM. Tyrosine phosphorylation is essential for microfilament assembly in B lymphocytes. Biochem Biophys Res Commun. 1991 May 15;176(3):1424-9. doi: 10.1016/0006-291x(91)90445-d. PMID: 2039521.