QD325 is a potent redox modulator for the Treatment of Pancreatic Ductal Adenocarcinoma. QD325 can induce substantial reactive oxygen species (ROS) in PDAC cells. Nascent RNA sequencing following treatments with QD325 revealed induction of stress responses in nucleus, endoplasmic reticulum, and mitochondria of pancreatic cancer cells. Furthermore, QD325 induced Nrf2-mediated oxidative stress and unfolded protein responses as demonstrated by dose dependent increases in RNA synthesis of representative genes such as NQO1, HMOX1, DDIT3 and HSPA5. QD325 is as a new therapeutic in the treatment of PDAC.
MedKoo Cat#: 407875
Name: QD325
CAS#: 2132410-88-7
Chemical Formula: C20H13N3O2
Exact Mass: 327.1008
Molecular Weight: 327.34
Elemental Analysis: C, 73.38; H, 4.00; N, 12.84; O, 9.78
The following data is based on the product molecular weight 327.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
