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MedKoo Cat#: 562017 | Name: PF2562

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF2562 is a non-catechol dopamine 1 receptor agonist. Dopamine D1 receptors are implicated in numerous neuropharmacological and neurobiological functions. For example, D1 receptors are involved in different types of memory function and synaptic plasticity.

Chemical Structure

PF2562
PF2562
CAS#1609258-91-4

Theoretical Analysis

MedKoo Cat#: 562017

Name: PF2562

CAS#: 1609258-91-4

Chemical Formula: C19H17N5O

Exact Mass: 331.1433

Molecular Weight: 331.38

Elemental Analysis: C, 68.87; H, 5.17; N, 21.13; O, 4.83

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No Data
Synonym
PF2562; PF-2562; PF 2562; PF-06412562; PF 06412562; PF06412562;
IUPAC/Chemical Name
4-[4-(4,6-Dimethyl-5-pyrimidinyl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine
InChi Key
IDIUJOHYYBNCPC-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H17N5O/c1-11-8-14(25-19-16-9-23-24-17(16)6-7-20-19)4-5-15(11)18-12(2)21-10-22-13(18)3/h4-10H,1-3H3,(H,23,24)
SMILES Code
CC1=CC(OC2=NC=CC3=C2C=NN3)=CC=C1C4=C(C)N=CN=C4C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
PF2562 (Example 6), a dopamine D1 ligand, acts as a dopamine D1 agonist or partial agonist.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 331.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
Lewis, M. M., Van Scoy, L. J., De Jesus, S., Hakun, J. G., Eslinger, P. J., Fernandez-Mendoza, J., ... & Mailman, R. B. (2023). Dopamine D1 agonists: first potential treatment for late-stage Parkinson’s disease. Biomolecules, 13(5), 829. Barret, O., Zhang, L., Alagille, D., Constantinescu, C. C., Sandiego, C., Papin, C., ... & Tamagnan, G. (2021). Dopamine D1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates. Journal of Nuclear Medicine, 62(9), 1307-1313. Tamagnan, G., Barret, O., Alagille, D., Carroll, V., Madonia, J., Constantinescu, C., ... & Marek, K. (2018). T156. In vivo characterization of the first agonist dopamine D1 receptors PET imaging tracer [18F] MNI-968 in human. Schizophrenia Bulletin, 44(Suppl 1), S176.