PF-06648671 is a γ-secretase modulator or Amyloid precursor protein secretase modulator for the treatment of neurodegenerative and/or neurological disorders such as Alzheimer’s disease and Down’s Syndrome. PF-06648671 decreased Aβ42 and Aβ40 concentrations in CSF, with greater effects on Aβ42, and increased Aβ37 and Aβ38 levels, particularly Aβ37. No significant change in total Aβ was observed. PF-06648671 resulted in robust, dose-dependent reductions in CSF Aβ42 and Aβ40 and elevations in Aβ37 and Aβ38, with no effect on total Aβ.
MedKoo Cat#: 562016
Name: PF-06648671
CAS#: 1587727-31-8
Chemical Formula: C25H23ClF4N4O3
Exact Mass: 538.1395
Molecular Weight: 538.93
Elemental Analysis: C, 55.72; H, 4.30; Cl, 6.58; F, 14.10; N, 10.40; O, 8.91
The following data is based on the product molecular weight 538.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
