MedKoo Cat#: 584287 | Name: Bts 39542

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bts 39542 is a diuretic. The ratio of the excretion of the major cations (sodium plus potassium) to that of the major anion (chloride) after BTS 39542 varied with species. In dogs, Bts 39542 exerts its major effects in the loop of Henle and increases renal blood flow but does not affect glomerular filtration rate.

Chemical Structure

Bts 39542
Bts 39542
CAS#57410-31-8

Theoretical Analysis

MedKoo Cat#: 584287

Name: Bts 39542

CAS#: 57410-31-8

Chemical Formula: C16H11ClN4O3S

Exact Mass: 374.0240

Molecular Weight: 374.80

Elemental Analysis: C, 51.27; H, 2.96; Cl, 9.46; N, 14.95; O, 12.81; S, 8.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Bts 39542; Bts39542; Bts-39542
IUPAC/Chemical Name
1-Phthalazineacetic acid, 2-(1,2,3-benzothiadiazol-5-yl)-7-chloro-1,2,3,4-tetrahydro-4-oxo-
InChi Key
YKRGBMIQMLLNND-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H11ClN4O3S/c17-8-1-3-10-11(5-8)13(7-15(22)23)21(19-16(10)24)9-2-4-14-12(6-9)18-20-25-14/h1-6,13H,7H2,(H,19,24)(H,22,23)
SMILES Code
O=C(O)CC1N(C2=CC=C(SN=N3)C3=C2)NC(C4=C1C=C(Cl)C=C4)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 374.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cooling MJ, Sim MF. BTS 39542, a dihydrophthalazin-1-ylacetic acid with high efficacy diuretic activity. Br J Pharmacol. 1981 Oct;74(2):359-64. PubMed PMID: 7317685; PubMed Central PMCID: PMC2071724. 2: Aiton JF, Simmons NL. Diuretic action of BTS 39542 (dihydrophthalazin-1-ylacetic acid) is consistent with inhibition of Na + K + Cl cotransport. Biochem Pharmacol. 1982 Sep 1;31(17):2827-30. PubMed PMID: 7138578.