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MedKoo Cat#: 584286 | Name: Btm 1042

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Btm 1042 is an antispasmodic drug that has been found to depress twitch responses in the ileum of guinea pig.

Chemical Structure

Btm 1042
Btm 1042
CAS#72293-40-4

Theoretical Analysis

MedKoo Cat#: 584286

Name: Btm 1042

CAS#: 72293-40-4

Chemical Formula: C21H27Cl2N3OS

Exact Mass: 439.1252

Molecular Weight: 440.43

Elemental Analysis: C, 57.27; H, 6.18; Cl, 16.10; N, 9.54; O, 3.63; S, 7.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Btm 1042; Btm1042; Btm-1042
IUPAC/Chemical Name
1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-((4-methyl-1-piperazinyl)methyl)-2-phenyl-, dihydrochloride, cis-(-)-
InChi Key
YRHGKQWXSOSAQX-RHXOVYDGSA-N
InChi Code
InChI=1S/C21H25N3OS.2ClH/c1-23-11-13-24(14-12-23)15-17-20(16-7-3-2-4-8-16)26-19-10-6-5-9-18(19)22-21(17)25;;/h2-10,17,20H,11-15H2,1H3,(H,22,25);2*1H/t17-,20+;;/m0../s1
SMILES Code
O=C1[C@@H](CN2CCN(C)CC2)[C@@H](C3=CC=CC=C3)SC4=CC=CC=C4N1.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 440.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Noronha-Blob L, Sturm BL, Lowe VC, Jackson KN, Kachur JF. In vitro and in vivo antimuscarinic effects of (-)cis 2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5 benzothiazepin-4-(5H)one HCl (BTM-1086) in guinea pig peripheral tissues. Life Sci. 1990;46(17):1223-31. PubMed PMID: 2338887. 2: Takayanagi I, Nakazo K, Kizawa Y. Possible mechanisms of a new type of antispasmodic drug, BTM-1042(cis-(--)-2,3-dihydro-3-(4-methyl-piperazinyl)methyl-2-phenyl-1,5-benzoth iazepin-4(5H)-one dihydrochloride). Jpn J Pharmacol. 1980 Oct;30(5):647-54. PubMed PMID: 7206371. 3: Yamamoto H, Nakamura Y, Nagasaka M, Asai H. Specificity in the pharmacological actions of optical isomers of cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5- benzothiazepin-4(5H)-one (BTM). Chem Pharm Bull (Tokyo). 1987 Aug;35(8):3419-24. PubMed PMID: 3427721. 4: Asano T, Okumura T, Hirano K, Adachi T, Sugiura M. Competitive enzyme immunoassay for anti-ulcer agent, (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5- benzothiazepin-4(5H)-one hydrochloride (BTM-1086). Chem Pharm Bull (Tokyo). 1986 Oct;34(10):4238-43. PubMed PMID: 3549012. 5: Ohno S, Izumi K, Mizukoshi K, Kato K, Hori M. Synthesis of a new potent anti-ulcer and gastric secretory inhibiting agent, (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5-benzothiazepin-4(5 H)-one hydrochloride (BTM-1086), and related compounds. Chem Pharm Bull (Tokyo). 1983 May;31(5):1780-3. PubMed PMID: 6616728. 6: Yamamoto H, Asai H. Effects of (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl- 1,5-benzothiaze pin-4-(5H)-one hydrochloride (BTM-1086) on ulceration, gastric secretion and mucosal blood flow in experimental animals. Chem Pharm Bull (Tokyo). 1986 Sep;34(9):3844-53. PubMed PMID: 3815606. 7: Eltze M, Boer R, Mutschler E, Lambrecht G. Affinity profiles of BTM-1086 and BTM-1041 at muscarinic receptor subtypes and at H1- and alpha 1-receptors. Eur J Pharmacol. 1989 Nov 7;170(3):225-34. PubMed PMID: 2575995. 8: Yamamoto H, Nakamura Y, Kunoh Y, Ichihara K, Nagasaka M, Asai H. Antiulcer effect of (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl) -2-phenyl-1,5-benzothiazepin-4-(5H)-one hydrochloride (BTM-1086) in experimental animals. Jpn J Pharmacol. 1986 Jul;41(3):283-92. PubMed PMID: 3761747. 9: Takayanagi I, Konno F, Akaike M, Nibori Y, Yamura S. cis(-)-2,3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5- benzothiazepin-4(5H)-one monohydrochloride and its butylbromide as M1-receptor antagonists. Gen Pharmacol. 1987;18(1):91-3. PubMed PMID: 3557056. 10: Murakami H, Ishikawa T, Watanabe H. Acetylcholine release elicited by electrical stimulation and its sites of action in smooth muscle of Mytilus. Comp Biochem Physiol C. 1984;77(2):273-7. PubMed PMID: 6144427. 11: Kromer W, Baron E, Boer R, Eltze M. Telenzepine inhibits electrically-stimulated, acetylcholine plus histamine-mediated acid secretion in the mouse isolated stomach by blockade of M1 muscarine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1991 Jan;343(1):7-13. PubMed PMID: 2030745. 12: Okumura T, Asano T, Adachi T, Hirano K. Enzyme immunoassay for the drug of anti-ulcer using avidin-biotin system. Chem Pharm Bull (Tokyo). 1991 Jul;39(7):1779-81. PubMed PMID: 1777930.

View History

NSC-82472

NSC-82472