Ziram | CAS#137-30-4 | fungicide

MedKoo Cat#: 341001 | Name: Ziram

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ziram, also known as Zinc dimethyldithiocarbamate, is a coordination complex of zinc with dimethyldithiocarbamate. It is a pale yellow solid that is used as a fungicide, the vulcanization of rubber, and other industrial applications.

Chemical Structure

Ziram

CAS#137-30-4

Theoretical Analysis

MedKoo Cat#: 341001

Name: Ziram

CAS#: 137-30-4

Chemical Formula: C6H12N2S4Zn

Exact Mass: 303.9175

Molecular Weight: 305.80

Elemental Analysis: C, 23.57; H, 3.96; N, 9.16; S, 41.94; Zn, 21.38

Price and Availability

Size	Price	Availability
25g	USD 350.00	2 Weeks
500g	USD 550.00	2 Weeks
1kg	USD 950.00	2 Weeks

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Related CAS #

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Synonym

Ziram; Zinc dimethyldithiocarbamate;

IUPAC/Chemical Name

Zinc, bis(dimethylcarbamodithioato-kappaS,kappaS')-, (T-4)-

InChi Key

DUBNHZYBDBBJHD-UHFFFAOYSA-L

InChi Code

InChI=1S/2C3H7NS2.Zn/c2*1-4(2)3(5)6;/h2*1-2H3,(H,5,6);/q;;+2/p-2

SMILES Code

C(=S)(N(C)C)[S-].[S-]C(N(C)C)=S.[Zn+2]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 305.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Ziram, a dithiocarbamate fungicide, exhibits pseudo-cytoprotective actions against oxidative stress in rat thymocytes: Possible environmental risks. Environ Res. 2018 Jan;160:232-238. doi: 10.1016/j.envres.2017.09.027. Epub 2017 Oct 10. PubMed PMID: 29028487. 5: Guo X, Zhou S, Chen Y, Chen X, Liu J, Ge F, Lian Q, Chen X, Ge RS. Ziram Delays Pubertal Development of Rat Leydig Cells. Toxicol Sci. 2017 Dec 1;160(2):329-340. doi: 10.1093/toxsci/kfx181. PubMed PMID: 28973382. 6: Chen L, Chen X, Chen X, Hu Z, Li X, Su Y, Li X, Ge RS. Ziram inhibits aromatase activity in human placenta and JEG-3 cell line. Steroids. 2017 Dec;128:114-119. doi: 10.1016/j.steroids.2017.09.006. Epub 2017 Sep 23. PubMed PMID: 28951168. 7: Su Y, Li H, Chen X, Wang Y, Li X, Sun J, Ge RS. Ziram inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase. Toxicol Mech Methods. 2018 Jan;28(1):38-44. doi: 10.1080/15376516.2017.1355950. PubMed PMID: 28707553. 8: Hass U, Christiansen S, Axelstad M, Scholze M, Boberg J. Combined exposure to low doses of pesticides causes decreased birth weights in rats. Reprod Toxicol. 2017 Sep;72:97-105. doi: 10.1016/j.reprotox.2017.05.004. Epub 2017 May 17. PubMed PMID: 28526456. 9: Al-Alam J, Bom L, Chbani A, Fajloun Z, Millet M. Analysis of Dithiocarbamate Fungicides in Vegetable Matrices Using HPLC-UV Followed by Atomic Absorption Spectrometry. J Chromatogr Sci. 2017 Apr 1;55(4):429-435. doi: 10.1093/chromsci/bmw198. PubMed PMID: 27999077. 10: Jung SM, Bae JS, Kang SG, Son JS, Jeon JH, Lee HJ, Jeon JY, Sidharthan M, Ryu SH, Shin HW. Acute toxicity of organic antifouling biocides to phytoplankton Nitzschia pungens and zooplankton Artemia larvae. Mar Pollut Bull. 2017 Nov 30;124(2):811-818. doi: 10.1016/j.marpolbul.2016.11.047. Epub 2016 Dec 2. PubMed PMID: 27919420. 11: Lulla A, Barnhill L, Bitan G, Ivanova MI, Nguyen B, O'Donnell K, Stahl MC, Yamashiro C, Klärner FG, Schrader T, Sagasti A, Bronstein JM. Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos. Environ Health Perspect. 2016 Nov;124(11):1766-1775. Epub 2016 Jun 15. PubMed PMID: 27301718; PubMed Central PMCID: PMC5089875. 12: Bei E, Liao X, Meng X, Li S, Wang J, Sheng D, Chao M, Chen Z, Zhang X, Chen C. Identification of nitrosamine precursors from urban drainage during storm events: A case study in southern China. Chemosphere. 2016 Oct;160:323-31. doi: 10.1016/j.chemosphere.2016.06.081. Epub 2016 Jul 6. PubMed PMID: 27393968. 13: Yılmaz E, Soylak M. Preparation and characterization of magnetic carboxylated nanodiamonds for vortex-assisted magnetic solid-phase extraction of ziram in food and water samples. Talanta. 2016 Sep 1;158:152-8. doi: 10.1016/j.talanta.2016.05.042. Epub 2016 May 14. PubMed PMID: 27343589. 14: Li X, Mao B, Dong Y, Li Y, Zhan M, Bai Y, Lian Q, Ge RS, Ye L. Effects of Ziram on Rat and Human 11β-Hydroxysteroid Dehydrogenase Isoforms. Chem Res Toxicol. 2016 Mar 21;29(3):398-405. doi: 10.1021/acs.chemrestox.5b00527. Epub 2016 Feb 18. PubMed PMID: 26859423. 15: Martin CA, Myers KM, Chen A, Martin NT, Barajas A, Schweizer FE, Krantz DE. Ziram, a pesticide associated with increased risk for Parkinson's disease, differentially affects the presynaptic function of aminergic and glutamatergic nerve terminals at the Drosophila neuromuscular junction. Exp Neurol. 2016 Jan;275 Pt 1:232-41. doi: 10.1016/j.expneurol.2015.09.017. Epub 2015 Oct 9. PubMed PMID: 26439313; PubMed Central PMCID: PMC4688233. 16: Kanemoto-Kataoka Y, Oyama TM, Ishibashi H, Oyama Y. Dithiocarbamate fungicides increase intracellular Zn(2+) levels by increasing influx of Zn(2+) in rat thymic lymphocytes. Chem Biol Interact. 2015 Jul 25;237:80-6. doi: 10.1016/j.cbi.2015.05.014. Epub 2015 May 27. PubMed PMID: 26026913. 17: Muroi M, Tanamoto K. Zinc- and oxidative property-dependent degradation of pro-caspase-1 and NLRP3 by ziram in mouse macrophages. Toxicol Lett. 2015 Jun 15;235(3):199-205. doi: 10.1016/j.toxlet.2015.04.012. Epub 2015 Apr 27. PubMed PMID: 25929180. 18: Li Q, Kobayashi M, Kawada T. Effect of carbamate pesticides on perforin, granzymes A-B-3/K, and granulysin in human natural killer cells. Int J Immunopathol Pharmacol. 2015 Sep;28(3):403-10. doi: 10.1177/0394632015582334. Epub 2015 Apr 28. PubMed PMID: 25921628. 19: Li Q, Kobayashi M, Kawada T. Carbamate pesticide-induced apoptosis in human T lymphocytes. Int J Environ Res Public Health. 2015 Apr 1;12(4):3633-45. doi: 10.3390/ijerph120403633. PubMed PMID: 25837344; PubMed Central PMCID: PMC4410207. 20: Dennis KE, Valentine WM. Ziram and sodium N,N-dimethyldithiocarbamate inhibit ubiquitin activation through intracellular metal transport and increased oxidative stress in HEK293 cells. 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