BRL 55834 | CAS#131899-25-7 | potassium channel activator

MedKoo Cat#: 584269 | Name: BRL 55834

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BRL 55834 is a potassium channel activator that has shown to relax airways and vasculature in vivo.

Chemical Structure

BRL 55834

CAS#131899-25-7

Theoretical Analysis

MedKoo Cat#: 584269

Name: BRL 55834

CAS#: 131899-25-7

Chemical Formula: C18H20F5NO3

Exact Mass: 393.1363

Molecular Weight: 393.35

Elemental Analysis: C, 54.96; H, 5.13; F, 24.15; N, 3.56; O, 12.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BRL 55834; BRL55834; BRL-55834

IUPAC/Chemical Name

2-Piperidinone, 1-(3,4-dihydro-3-hydroxy-2,2-dimethyl-6-(pentafluoroethyl)-2H-1-benzopyran-4-yl)-, (3S-trans)-

InChi Key

ZSUFQZNGDIXQAD-CABCVRRESA-N

InChi Code

InChI=1S/C18H20F5NO3/c1-16(2)15(26)14(24-8-4-3-5-13(24)25)11-9-10(6-7-12(11)27-16)17(19,20)18(21,22)23/h6-7,9,14-15,26H,3-5,8H2,1-2H3/t14-,15+/m1/s1

SMILES Code

O=C1N([C@H]2[C@H](O)C(C)(C)OC3=CC=C(C(F)(F)C(F)(F)F)C=C23)CCCC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 393.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bowring NE, Arch JR, Buckle DR, Taylor JF. Comparison of the airways relaxant and hypotensive potencies of the potassium channel activators BRL 55834 and levcromakalim (BRL 38227) in vivo in guinea-pigs and rats. Br J Pharmacol. 1993 Aug;109(4):1133-9. PubMed PMID: 8401925; PubMed Central PMCID: PMC2175747. 2: Arch JR, Bowring NE, Buckle DR. Evaluation of the novel potassium channel activator BRL 55834 as an inhaled bronchodilator in guinea-pigs and rats: comparison with levcromakalim and salbutamol. Pulm Pharmacol. 1994 Apr;7(2):121-8. PubMed PMID: 8081072. 3: Shi Z, Yan Z, Luo W. [Antigen-induced airway leakage in asthmatic guinea-pigs and the effects of BRL 55834]. Zhonghua Jie He He Hu Xi Za Zhi. 1998 Apr;21(4):229-32. Chinese. PubMed PMID: 11326971. 4: Shi Z, Luo W, Xiu Q, Ye Y, Yan Z, Zhu Q. Effects of BRL 55 834 on allergen-induced bronchoconstriction and airway inflammation in sensitized guinea pigs. Chin Med J (Engl). 1999 Nov;112(11):988-91. PubMed PMID: 11721481. 5: Edwards G, Schneider J, Niederste-Hollenberg A, Noack T, Weston AH. Effects of BRL55834 in rat portal vein and bovine trachea: evidence for the induction of a glibenclamide-resistant, ATP-sensitive potassium current. Br J Pharmacol. 1995 Jul;115(6):1027-37. PubMed PMID: 7582499; PubMed Central PMCID: PMC1909032.