Synonym
Brl 22321; Brl22321; Brl-22321
IUPAC/Chemical Name
1H-Naphtho(2,3-d)triazole-4,9-dione, 6,7-dimethyl-
InChi Key
ACMSQMLLTIBBEG-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H9N3O2/c1-5-3-7-8(4-6(5)2)12(17)10-9(11(7)16)13-15-14-10/h3-4H,1-2H3,(H,13,14,15)
SMILES Code
O=C(C1=C2NN=N1)C3=C(C=C(C)C(C)=C3)C2=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
227.22
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Smith H, Ross JW, Spicer BA, Clarke GD, Harling EJ, Hassall PA, Taylor JF. BRL 22321. A compound with similarities to both disodium cromoglycate and theophylline. Monogr Allergy. 1983;18:223-5. PubMed PMID: 6196629.
2: Spicer BA, Ross JW, Clarke GD, Harling EJ, Hassall PA, Smith H, Taylor JF. BRL 22321, a compound that has mast cell stabilizing activity similar to that of disodium cromoglycate and in addition has smooth muscle relaxing activity. Agents Actions. 1983 Jun;13(4):301-9. PubMed PMID: 6193695.
3: Cockerham LG, Doyle TF, Pautler EL, Hampton JD. Disodium cromoglycate, a mast-cell stabilizer, alters postradiation regional cerebral blood flow in primates. J Toxicol Environ Health. 1986;18(1):91-101. PubMed PMID: 3084803.
