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MedKoo Cat#: 584256 | Name: Ambazone hydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ambazone hydrate is an anti-cancer agent.

Chemical Structure

Ambazone hydrate
Ambazone hydrate
CAS#6011-12-7

Theoretical Analysis

MedKoo Cat#: 584256

Name: Ambazone hydrate

CAS#: 6011-12-7

Chemical Formula: C8H13N7OS

Exact Mass: 255.0902

Molecular Weight: 255.30

Elemental Analysis: C, 37.64; H, 5.13; N, 38.41; O, 6.27; S, 12.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ambazone hydrate
IUPAC/Chemical Name
1,4-Benzoquinone guanylhydrazone thiosemicarbazone hydrate
InChi Key
IEMLQLDCDHGTMI-IOHAXTJFSA-N
InChi Code
InChI=1S/C8H11N7S.H2O/c9-7(10)14-12-5-1-3-6(4-2-5)13-15-8(11)16;/h1-4H,(H4,9,10,14)(H3,11,15,16);1H2/b12-5-,13-6+;
SMILES Code
N=C(N/N=C(C=C/1)/C=CC1=N/NC(N)=S)N.[H]O[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 255.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Muresan-Pop M, Braga D, Pop MM, Borodi G, Kacso I, Maini L. Crystal structure and physicochemical characterization of ambazone monohydrate, anhydrous, and acetate salt solvate. J Pharm Sci. 2014 Nov;103(11):3594-3601. doi: 10.1002/jps.24151. Epub 2014 Sep 3. PubMed PMID: 25187325. 2: Choi J, Jee JG. Repositioning of Thiourea-Containing Drugs as Tyrosinase Inhibitors. Int J Mol Sci. 2015 Dec 2;16(12):28534-48. doi: 10.3390/ijms161226114. PubMed PMID: 26633377; PubMed Central PMCID: PMC4691061. 3: Gutsche W, Härtl A, Baumgart J, Schulze W. [Antineoplastic activity and toxicity of dihydroambazone in comparison with ambazone (1,4-benzoquinone-guanylhydrazone-thiosemicarbazone)]. Pharmazie. 1990 Jan;45(1):55-7. German. PubMed PMID: 2333315. 4: Amlacher R, Kühnel HJ, Niemann G, Schulze W. Pharmacokinetics of 14C-ambazone (1,4-benzochinone-guanylhydrazone-14C-thiosemicarbazone) in B6D2F1 mice. Pharmazie. 1986 Feb;41(2):155. PubMed PMID: 3725860. 5: Kühnel HJ, Amlacher R, Kramarczyk K, Schulze W. Pharmacokinetics of 14C-ambazone in rats. Pharmazie. 1988 Mar;43(3):197-9. PubMed PMID: 3380864. 6: Miosga N, Roemer W, Amlacher R. [Kinetics of the transformation of dihydroambazone into ambazone]. Pharmazie. 1990 Jan;45(1):41-2. German. PubMed PMID: 2333311. 7: Baumgart J, Wisniewski HG, Amlacher R, Zhukovskaya NV, Rentz E. Age-dependent antileukemic action and suppression of immune response by 1,4-benzoquinone-guanylhydrazone-thiosemicarbazone (ambazone) in mice. Neoplasma. 1989;36(4):393-400. PubMed PMID: 2770926. 8: Amlacher R, Baumgart J, Härtl A, Weber H, Kühnel HJ, Schulze W, Hoffmann H. Influence of age on antileukemic action, subacute toxicity and tissue distribution of ambazone in B6D2F1 mice. Arch Geschwulstforsch. 1990;60(1):11-8. PubMed PMID: 2310296. 9: Fulga I, Neguţ M, Năşcuţiu AM, Nemet C, Toma F, Grigore L, Niţescu R, Marcu C, Nedelcu L, Spircu T. [Microbial sensitivity to ambazone (Faringosept) in pharyngeal samples from patients with acute infections of the upper respiratory tract]. Bacteriol Virusol Parazitol Epidemiol. 2007 Jan-Jun;52(1-2):19-27. Romanian. PubMed PMID: 18441955. 10: Kühnel HJ, Amlacher R, Baumgart J, Schulze W. Distribution of 14C-ambazone in normal and leukemia P 388-bearing mice. Arch Geschwulstforsch. 1988;58(4):217-22. PubMed PMID: 3421808. 11: Amlacher R, Mackowiak A, Baumgart J, Schulze W, Hoffmann H. Influence of murine melanoma B16 on the distribution of ambazone in B6D2F1 mice. Pharmazie. 1990 May;45(5):379-80. PubMed PMID: 2395907. 12: Baumgart J, Zhukovskaya NV, Anisimov VN. Carcinogenesis and aging. VIII. Effect of host age on tumour growth, metastatic potential, and chemotherapeutic sensitivity to 1.4-benzoquinone-guanylhydrazonethiosemicarbazone (ambazone) and 5-fluorouracil in mice and rats. Exp Pathol. 1988;33(4):239-48. PubMed PMID: 3229459. 13: Kuhnke G, Göckeritz D, Pohlaudek-Fabini R. [Quantitative determination of ambazone]. Pharmazie. 1976 Nov;31(11):820-1. German. PubMed PMID: 1023255. 14: Löber G, Hoffmann H. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300. Review. PubMed PMID: 2204445. 15: Hacker E, Kossowicz J, Milde K. The protection of insulin against proteolytic processes after rectal application to normoglycemic rabbits. Pharmazie. 1991 Feb;46(2):125-7. PubMed PMID: 1712971. 16: Löber G, Geller K, Hanschmann H, Popa LM, Repanovici R, Iliescu R, Römer W, Janke B, Kleinwächter V. Cationic anticancer drugs and their modes of action. Physiologie. 1989 Oct-Dec;26(4):305-16. PubMed PMID: 2561492. 17: Baumgart J, Güttner J, Zborowska E, Czarnomska A. Biological characterization of three new spontaneous mouse lymphomas and comparison with the leukemia P388. Arch Geschwulstforsch. 1988;58(4):223-33. PubMed PMID: 3421809. 18: Miosga N, Schulze W, Hesse G, Römer W. Chemical-analytical characterization of dihydroambazone. Pharmazie. 1988 Aug;43(8):541-3. PubMed PMID: 3237743. 19: Janke B. [The effect of ambazone and ambazone derivatives on immunologic processes in human lymphocytes]. Pharmazie. 1990 Feb;45(2):126-7. German. PubMed PMID: 2339169. 20: Gutsche W, Stelzner A. Preselection of Potential Cancerostatics by Automatic Analysis of Suspended and Adherent Cells Incubated in Microplates. Altern Lab Anim. 1997 Jan-Feb;25(1):45-54. PubMed PMID: 26554349.

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Ambazone

Ambazone