Synonym
BO 1341; BO1341; BO-1341
IUPAC/Chemical Name
Isoquinolinium, 2-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydroxy-, hydroxide, inner salt, (6R-trans)-
InChi Key
XMOLQYFYIRKUAY-PLEZTBHSSA-N
InChi Code
InChI=1S/C26H24N6O9S2/c1-26(2,24(39)40)41-30-17(14-10-43-25(27)28-14)20(35)29-18-21(36)32-19(23(37)38)13(9-42-22(18)32)8-31-4-3-11-5-15(33)16(34)6-12(11)7-31/h3-7,10,18,22H,8-9H2,1-2H3,(H6,27,28,29,34,35,37,38,39,40)/b30-17+/t18-,22-/m1/s1
SMILES Code
OC1=CC2=C[N+](CC(CS[C@]3([H])[C@@H]4NC(/C(C5=CSC(N)=N5)=N/OC(C)(C(O)=O)C)=O)=C(C([O-])=O)N3C4=O)=CC=C2C=C1O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
628.63
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hazumi N, Matsuda K, Sanada M, Ohtake N, Tanaka N. Resistance to a new catecholic cephem, BO-1341, in Pseudomonas aeruginosa PAO. J Antimicrob Chemother. 1992 Mar;29(3):287-97. PubMed PMID: 1592698.
2: Nakagawa S, Sanada M, Matsuda K, Hashizume T, Asahi Y, Ushijima R, Ohtake N, Tanaka N. In vitro and in vivo antibacterial activities of BO-1341, a new antipseudomonal cephalosporin. Antimicrob Agents Chemother. 1989 Sep;33(9):1423-7. PubMed PMID: 2510590; PubMed Central PMCID: PMC172677.
3: Sanada M, Hashizume T, Matsuda K, Nakagawa S, Tanaka N. Mode of action of BO-1341: transport pathway through the outer membrane of Escherichia coli. Drugs Exp Clin Res. 1988;14(6):397-402. PubMed PMID: 3063475.
4: Hashizume T, Sanada M, Nakagawa S, Tanaka N. Comparison of transport pathways of catechol-substituted cephalosporins, BO-1236 and BO-1341, through the outer membrane of Escherichia coli. J Antibiot (Tokyo). 1990 Dec;43(12):1617-20. PubMed PMID: 2276982.
