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MedKoo Cat#: 581059 | Name: GABAA Modulator I

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GABAA Modulator I is novel modulator of the GABAA receptor complex, and in particular for combating anxiety and related diseases.

Chemical Structure

GABAA Modulator I
GABAA Modulator I
CAS#951654-29-8

Theoretical Analysis

MedKoo Cat#: 581059

Name: GABAA Modulator I

CAS#: 951654-29-8

Chemical Formula: C23H21N3O2

Exact Mass: 371.1634

Molecular Weight: 371.44

Elemental Analysis: C, 74.37; H, 5.70; N, 11.31; O, 8.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
GABAA Modulator I; 3'-(5-(2-Hydroxypropan-2-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-2-carboxamide; SCHEMBL1761811; MFCD30186081; AKOS027439948; ZINC117027649
IUPAC/Chemical Name
2-[3-[5-(2-Hydroxypropan-2-yl)benzimidazol-1-yl]phenyl]benzamide
InChi Key
XOUVTIGDGKTSAA-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H21N3O2/c1-23(2,28)16-10-11-21-20(13-16)25-14-26(21)17-7-5-6-15(12-17)18-8-3-4-9-19(18)22(24)27/h3-14,28H,1-2H3,(H2,24,27)
SMILES Code
O=C(N)C1=CC=CC=C1C2=CC=CC(N3C4=CC=C(C(C)(O)C)C=C4N=C3)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 371.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Administration of Alpha(s1)-Casein Hydrolysate Increases Sleep and Modulates GABA(A) Receptor Subunit Expression. Biomol Ther (Seoul). 2018 Jan 9. doi: 10.4062/biomolther.2017.083. [Epub ahead of print] PubMed PMID: 29316237. 5: Artelsmair M, Gu C, Lewis RJ, Elmore CS. Synthesis of C-14 Labeled GABA(A) α2/α3 Selective Partial Agonists and the Investigation of Late-Occurring and Long-Circulating Metabolites of GABA(A) Receptor Modulator AZD7325. J Labelled Comp Radiopharm. 2018 Jan 4. doi: 10.1002/jlcr.3602. [Epub ahead of print] PubMed PMID: 29314165. 6: Bazzurro V, Gatta E, Cupello A, Lange S, Robello M. Antisecretory Factor Modulates GABA(A) Receptor Activity in Neurons. J Mol Neurosci. 2018 Jan 7. doi: 10.1007/s12031-017-1024-8. [Epub ahead of print] PubMed PMID: 29308551. 7: Tschumi CW, Beckstead MJ. Neurotensin speeds inhibition of dopamine neurons through temporal modulation of GABA(A) and GABA(B) receptor-mediated synaptic input. Neuropharmacology. 2018 Jan 4. pii: S0028-3908(18)30004-2. doi: 10.1016/j.neuropharm.2018.01.004. [Epub ahead of print] PubMed PMID: 29307543. 8: Feng HJ, Forman SA. Comparison of αβδ and αβγ GABA(A) receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2017 Dec 30. pii: S1043-6618(17)31024-1. doi: 10.1016/j.phrs.2017.12.031. [Epub ahead of print] Review. PubMed PMID: 29294355. 9: Neugebauer NM, Miyauchi M, Sato T, Tadano J, Akal H, Ardehali H, Meltzer HY. Hippocampal GABA(A) antagonism reverses the novel object recognition deficit in sub-chronic phencyclidine-treated rats. Behav Brain Res. 2017 Dec 28;342:11-18. doi: 10.1016/j.bbr.2017.12.033. [Epub ahead of print] PubMed PMID: 29289597. 10: Miller SM, Pelly S, Kalanjati VP, Lee A, Colditz PB, Bjorkman ST. Identification and expression of a unique neonatal variant of the GABA(A) receptor α(3) subunit. Brain Struct Funct. 2017 Dec 27. doi: 10.1007/s00429-017-1597-6. [Epub ahead of print] PubMed PMID: 29282556. 11: Montandon G, Wu H, Liu H, Vu MT, Orser BA, Horner RL. δ-Subunit Containing GABA(A) Receptors Modulate Respiratory Networks. Sci Rep. 2017 Dec 22;7(1):18105. doi: 10.1038/s41598-017-17379-x. PubMed PMID: 29273726; PubMed Central PMCID: PMC5741762. 12: Figlerowicz M, Kemnitz P, Mania A, Mazur-Melewska K, Tomczak E, Kuls K, Jończyk-Potoczna K, Graus F, Służewski W. Autoimmune encephalitis with GABA(A) receptor antibodies in a 10-year-old girl. Clin Neurol Neurosurg. 2017 Dec 12;164:160-163. doi: 10.1016/j.clineuro.2017.12.012. [Epub ahead of print] PubMed PMID: 29245105. 13: Liu JP, He YT, Duan XL, Suo ZW, Yang X, Hu XD. Enhanced Activities of δ Subunit-containing GABA(A) Receptors Blocked Spinal Long-term Potentiation and Attenuated Formalin-induced Spontaneous Pain. Neuroscience. 2017 Dec 8;371:155-165. doi: 10.1016/j.neuroscience.2017.12.002. [Epub ahead of print] PubMed PMID: 29229558. 14: Zabela V, Hettich T, Schlotterbeck G, Wimmer L, Mihovilovic MD, Guillet F, Bouaita B, Shevchenko B, Hamburger M, Oufir M. GABA(A) receptor activity modulating piperine analogs: In vitro metabolic stability, metabolite identification, CYP450 reaction phenotyping, and protein binding. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:379-389. doi: 10.1016/j.jchromb.2017.11.036. Epub 2017 Dec 2. PubMed PMID: 29227934. 15: Wu XH, Song JJ, Faull RLM, Waldvogel HJ. GABA(A) and GABA(B) receptor subunit localization on neurochemically identified neurons of the human subthalamic nucleus. J Comp Neurol. 2017 Dec 8. doi: 10.1002/cne.24368. [Epub ahead of print] PubMed PMID: 29218727. 16: Kanatani S, Fuks JM, Olafsson EB, Westermark L, Chambers B, Varas-Godoy M, Uhlén P, Barragan A. Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii. PLoS Pathog. 2017 Dec 7;13(12):e1006739. doi: 10.1371/journal.ppat.1006739. eCollection 2017 Dec. PubMed PMID: 29216332; PubMed Central PMCID: PMC5720541. 17: Gagnon M, Bergeron MJ, Perez-Sanchez J, Plasencia-Fernández I, Lorenzo LE, Godin AG, Castonguay A, Bonin RP, De Koninck Y. Reply to The small molecule CLP257 does not modify activity of the K(+)-Cl(-) co-transporter KCC2 but does potentiate GABA(A) receptor activity. Nat Med. 2017 Dec 7;23(12):1396-1398. doi: 10.1038/nm.4449. PubMed PMID: 29216044. 18: Cardarelli RA, Jones K, Pisella LI, Wobst HJ, McWilliams LJ, Sharpe PM, Burnham MP, Baker DJ, Chudotvorova I, Guyot J, Silayeva L, Morrow DH, Dekker N, Zicha S, Davies PA, Holenz J, Duggan ME, Dunlop J, Mather RJ, Wang Q, Medina I, Brandon NJ, Deeb TZ, Moss SJ. The small molecule CLP257 does not modify activity of the K(+)-Cl(-) co-transporter KCC2 but does potentiate GABA(A) receptor activity. Nat Med. 2017 Dec 7;23(12):1394-1396. doi: 10.1038/nm.4442. PubMed PMID: 29216042. 19: Nickolls SA, Gurrell R, van Amerongen G, Kammonen J, Cao L, Brown AR, Stead C, Mead A, Watson C, Hsu C, Owen RM, Pike A, Fish RL, Chen L, Qiu R, Morris ED, Feng G, Whitlock M, Gorman D, van Gerven J, Reynolds DS, Dua P, Butt RP. Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABA(A) receptor positive allosteric modulator PF-06372865. Br J Pharmacol. 2017 Dec 7. doi: 10.1111/bph.14119. [Epub ahead of print] PubMed PMID: 29214652. 20: Chandler CM, Overton JS, Rüedi-Bettschen D, Platt DM. GABA(A) Receptor Subtype Mechanisms and the Abuse-Related Effects of Ethanol: Genetic and Pharmacological Evidence. Handb Exp Pharmacol. 2017 Dec 5. doi: 10.1007/164_2017_80. [Epub ahead of print] PubMed PMID: 29204713.

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