MedKoo Cat#: 581058 | Name: ABT-472

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ABT-472, Novel PARP inhibitor

Chemical Structure

ABT-472
CAS#943650-25-7

Theoretical Analysis

MedKoo Cat#: 581058

Name: ABT-472

CAS#: 943650-25-7

Chemical Formula: C20H28N4O5

Exact Mass: 404.2060

Molecular Weight: 404.48

Elemental Analysis: C, 59.39; H, 6.98; N, 13.85; O, 19.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
ABT-472; 2-(1-Propylpiperidin-4-yl)-1H-benzo[d]imidazole-7-carboxamide succinate; ABT-472; A-620223 (HCl salt); DTXSID70670431; AKOS016845980
IUPAC/Chemical Name
2-(1-Propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide Succinate
InChi Key
GWFBXGWIRCSOAO-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H22N4O.C4H6O4/c1-2-8-20-9-6-11(7-10-20)16-18-13-5-3-4-12(15(17)21)14(13)19-16;5-3(6)1-2-4(7)8/h3-5,11H,2,6-10H2,1H3,(H2,17,21)(H,18,19);1-2H2,(H,5,6)(H,7,8)
SMILES Code
O=C(C1=C2N=C(C3CCN(CCC)CC3)NC2=CC=C1)N.O=C(O)CCC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 404.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Saqib U, Baig MS. Probing PARP1-inhibitor complexes for the development of novel inhibitors. Cell Mol Biol (Noisy-le-grand). 2014 Oct 25;60(3):43-52. PubMed PMID: 25346248. 2: Process Development for ABT-472, a Benzimidazole PARP Inhibitor Org. Process Res. Dev., 2007, 11 (4), pp 693–698 DOI: 10.1021/op7000194 Publication Date (Web): May 15, 2007 Copyright © 2007 American Chemical Society. 3: Synthesis of the Quinolone ABT-492:  Crystallizations for Optimal Processing Org. Process Res. Dev., 2006, 10 (4), pp 751–756 DOI: 10.1021/op060054e Publication Date (Web): June 23, 2006 Copyright © 2006 American Chemical Society.