Synonym
PU139; PU-139; PU 139
IUPAC/Chemical Name
2-(4-Fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
InChi Key
QMCIVCACYJRAAY-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H7FN2OS/c13-8-3-5-9(6-4-8)15-12(16)10-2-1-7-14-11(10)17-15/h1-7H
SMILES Code
O=C1N(C2=CC=C(F)C=C2)SC3=NC=CC=C31
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
246.26
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cheng Y, Ning K, Chen Y, Hou C, Yu H, Yu H, Chen S, Guo X, Dong L. Identification of histone acetyltransferase genes responsible for cannabinoid synthesis in hemp. Chin Med. 2023 Feb 13;18(1):16. doi: 10.1186/s13020-023-00720-0. PMID: 36782242; PMCID: PMC9926835.
2: Ramakrishnan J, Magudeeswaran S, Suresh S, Poomani K. Investigation of intermolecular interactions and binding mechanism of PU139 and PU141 molecules with p300 HAT enzyme via molecular docking, molecular dynamics simulations and binding free energy analysis. J Biomol Struct Dyn. 2023 Mar;41(4):1351-1365. doi: 10.1080/07391102.2021.2020164. Epub 2022 Jan 3. PMID: 34974819.
3: Gajer JM, Furdas SD, Gründer A, Gothwal M, Heinicke U, Keller K, Colland F, Fulda S, Pahl HL, Fichtner I, Sippl W, Jung M. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis. 2015 Feb 9;4(2):e137. doi: 10.1038/oncsis.2014.51. PMID: 25664930; PMCID: PMC4338425.
4: Carneiro VC, de Abreu da Silva IC, Torres EJ, Caby S, Lancelot J, Vanderstraete M, Furdas SD, Jung M, Pierce RJ, Fantappié MR. Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis. PLoS Pathog. 2014 May 8;10(5):e1004116. doi: 10.1371/journal.ppat.1004116. PMID: 24809504; PMCID: PMC4014452.
