MedKoo Cat#: 527667 | Name: Antimycin A complex
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Antimycin A complex is a bacterial metabolite complex that has been found in Streptomyces and is composed of the major components antimycin A1, -A2, -A3 , and -A4 , as well as minor components, including antimycin A5 and -A6, among others. It induces the synthesis of carotenoids in M. marinum when used at concentrations ranging from 3.3 to 160 µM.2 Antimycin A complex (25-125 ppb) has teleocidal activity against goldfish. Note: This product has purity ≥95% (contained mixture of subunits).

Chemical Structure

Antimycin A complex
Antimycin A complex
CAS#1397-94-0

Theoretical Analysis

MedKoo Cat#: 527667

Name: Antimycin A complex

CAS#: 1397-94-0

Chemical Formula: C28H40N2O9

Exact Mass: 548.2734

Molecular Weight: 548.63

Elemental Analysis: C, 61.30; H, 7.35; N, 5.11; O, 26.25

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Antimycin A
IUPAC/Chemical Name
[(2R,3S,6S,7R,8R)-3-[(3-Formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
InChi Key
UIFFUZWRFRDZJC-SBOOETFBSA-N
InChi Code
InChI=1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20-,23+,25+/m1/s1
SMILES Code
CC(C)CC(O[C@H]([C@H]1CCCCCC)[C@H](C)OC([C@@H](NC(C2=CC=CC(NC=O)=C2O)=O)[C@@H](C)OC1=O)=O)=O
Appearance
Solid powder
Purity
≥95% (mixture of subunits)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Antimycin A is an antibiotic, inducing apoptosis and inhibiting the mitochondrial electron transport chain from cytochrome b to cytochrome C1, disrupting the ABCC4-MPP1 protein complex and reversing drug resistance in AML cell lines and in primary patient AML cells.

Preparing Stock Solutions

The following data is based on the product molecular weight 548.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Broda M, Van Aken O. Studying Retrograde Signaling in Plants. Methods Mol Biol. 2018;1743:73-85. doi: 10.1007/978-1-4939-7668-3_7. PubMed PMID: 29332287. 2: Teixeira J, Basit F, Swarts HG, Forkink M, Oliveira PJ, Willems PHGM, Koopman WJH. Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells. Redox Biol. 2017 Dec 30;15:394-404. doi: 10.1016/j.redox.2017.12.018. [Epub ahead of print] PubMed PMID: 29331741; PubMed Central PMCID: PMC5767902. 3: He Y, Khan I, Bai X, Odle J, Xi L. Activation of PPARα by Oral Clofibrate Increases Renal Fatty Acid Oxidation in Developing Pigs. Int J Mol Sci. 2017 Dec 8;18(12). pii: E2663. doi: 10.3390/ijms18122663. PubMed PMID: 29292738; PubMed Central PMCID: PMC5751265. 4: Li XY, Wu J, Luo D, Chen WX, Zhu GL, Zhang YX, Bi ZM, Feng BH. [Effect of high glucose-based peritoneal dialysis fluids on NLRP3-IL-1β in human peritoneal mesothelial cells]. Beijing Da Xue Xue Bao Yi Xue Ban. 2017 Dec 18;49(6):954-960. Chinese. PubMed PMID: 29263464. 5: Zhang Y, Ao X, Li H, Deng S, Xiao Z, Peng W, Xiang J, Zhou Q. [Cordyceps sinensis protects HK2 cells from ischemia-reperfusion injury through Sirt1 pathway]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Nov 28;42(11):1263-1269. doi: 10.11817/j.issn.1672-7347.2017.11.004. Chinese. PubMed PMID: 29187652. 6: Hirusaki K, Yokoyama K, Cho K, Ohta Y. Temporal depolarization of mitochondria during M phase. Sci Rep. 2017 Nov 22;7(1):16044. doi: 10.1038/s41598-017-15907-3. PubMed PMID: 29167496; PubMed Central PMCID: PMC5700041. 7: Dikalov SI, Mayorov VI, Panov AV. Physiological Levels of Nitric Oxide Diminish Mitochondrial Superoxide. Potential Role of Mitochondrial Dinitrosyl Iron Complexes and Nitrosothiols. Front Physiol. 2017 Nov 7;8:907. doi: 10.3389/fphys.2017.00907. eCollection 2017. PubMed PMID: 29163230; PubMed Central PMCID: PMC5681960. 8: Pitre A, Ge Y, Lin W, Wang Y, Fukuda Y, Temirov J, Phillips AH, Peters JL, Fan Y, Ma J, Nourse A, Sinha C, Lin H, Kriwacki R, Downing JR, Gruber TA, Centonze VE, Naren AP, Chen T, Schuetz JD. An unexpected protein interaction promotes drug resistance in leukemia. Nat Commun. 2017 Nov 16;8(1):1547. doi: 10.1038/s41467-017-01678-y. PubMed PMID: 29146910; PubMed Central PMCID: PMC5691054. 9: Chen W, Sandoval H, Kubiak JZ, Li XC, Ghobrial RM, Kloc M. The phenotype of peritoneal mouse macrophages depends on the mitochondria and ATP/ADP homeostasis. Cell Immunol. 2017 Nov 7. pii: S0008-8749(17)30199-5. doi: 10.1016/j.cellimm.2017.11.003. [Epub ahead of print] PubMed PMID: 29129293. 10: Mallick S, Thuy LT, Lee S, Park JI, Choi JS. Liposomes containing cholesterol and mitochondria-penetrating peptide (MPP) for targeted delivery of antimycin A to A549 cells. Colloids Surf B Biointerfaces. 2018 Jan 1;161:356-364. doi: 10.1016/j.colsurfb.2017.10.052. Epub 2017 Oct 18. PubMed PMID: 29100129. 11: Corver WE, Demmers J, Oosting J, Sahraeian S, Boot A, Ruano D, Wezel TV, Morreau H. ROS-induced near-homozygous genomes in thyroid cancer. Endocr Relat Cancer. 2018 Jan;25(1):83-97. doi: 10.1530/ERC-17-0288. Epub 2017 Oct 24. PubMed PMID: 29066502. 12: Lambooij JM, Hoogenkamp MA, Brandt BW, Janus MM, Krom BP. Fungal mitochondrial oxygen consumption induces the growth of strict anaerobic bacteria. Fungal Genet Biol. 2017 Dec;109:1-6. doi: 10.1016/j.fgb.2017.10.001. Epub 2017 Oct 5. PubMed PMID: 28989089. 13: Bazil JN. Analysis of a Functional Dimer Model of Ubiquinol Cytochrome c Oxidoreductase. Biophys J. 2017 Oct 3;113(7):1599-1612. doi: 10.1016/j.bpj.2017.08.018. PubMed PMID: 28978450; PubMed Central PMCID: PMC5627346. 14: Young DH, Wang NX, Meyer ST, Avila-Adame C. Characterization of the mechanism of action of the fungicide fenpicoxamid and its metabolite UK-2A. Pest Manag Sci. 2018 Feb;74(2):489-498. doi: 10.1002/ps.4743. Epub 2017 Nov 14. PubMed PMID: 28960782. 15: Dong W, Li Z, Chen Y, Zhang L, Ye Z, Liang H, Li R, Xu L, Zhang B, Liu S, Wang W, Li C, Luo J, Shi W, Liang X. NADPH oxidase inhibitor, diphenyleneiodonium prevents necroptosis in HK-2 cells. Biomed Rep. 2017 Sep;7(3):226-230. doi: 10.3892/br.2017.948. Epub 2017 Jul 21. PubMed PMID: 28894570; PubMed Central PMCID: PMC5582581. 16: Kanaporis G, Treinys R, Fischmeister R, Jurevičius J. Metabolic inhibition reduces cardiac L-type Ca2+ channel current due to acidification caused by ATP hydrolysis. PLoS One. 2017 Aug 31;12(8):e0184246. doi: 10.1371/journal.pone.0184246. eCollection 2017. PubMed PMID: 28859158; PubMed Central PMCID: PMC5578678. 17: Ohshima Y, Takata N, Suzuki-Karasaki M, Yoshida Y, Tokuhashi Y, Suzuki-Karasaki Y. Disrupting mitochondrial Ca2+ homeostasis causes tumor-selective TRAIL sensitization through mitochondrial network abnormalities. Int J Oncol. 2017 Oct;51(4):1146-1158. doi: 10.3892/ijo.2017.4096. Epub 2017 Aug 11. PubMed PMID: 28849210. 18: Trevijano-Contador N, Rossi SA, Alves E, Landín-Ferreiroa S, Zaragoza O. Capsule Enlargement in Cryptococcus neoformans Is Dependent on Mitochondrial Activity. Front Microbiol. 2017 Jul 31;8:1423. doi: 10.3389/fmicb.2017.01423. eCollection 2017. PubMed PMID: 28824559; PubMed Central PMCID: PMC5534456. 19: Karpinska B, Alomrani SO, Foyer CH. Inhibitor-induced oxidation of the nucleus and cytosol in Arabidopsis thaliana: implications for organelle to nucleus retrograde signalling. Philos Trans R Soc Lond B Biol Sci. 2017 Sep 26;372(1730). pii: 20160392. doi: 10.1098/rstb.2016.0392. PubMed PMID: 28808105; PubMed Central PMCID: PMC5566886. 20: Zapotoczny B, Szafranska K, Owczarczyk K, Kus E, Chlopicki S, Szymonski M. Atomic Force Microscopy Reveals the Dynamic Morphology of Fenestrations in Live Liver Sinusoidal Endothelial Cells. Sci Rep. 2017 Aug 11;7(1):7994. doi: 10.1038/s41598-017-08555-0. PubMed PMID: 28801568; PubMed Central PMCID: PMC5554186.